{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:40:50Z","timestamp":1762875650097},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,28]],"date-time":"2014-12-28T00:00:00Z","timestamp":1419724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the clinical relevance and cost\u2010effectiveness of human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>)\u2010genotyping in the Netherlands as a screening tool for the development of coeliac disease in children with Type\u00a01 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was performed in 110 children with Type 1 diabetes mellitus diagnosed between January 1996 and January 2013. All children were screened for coeliac disease using coeliac disease\u2010specific antibodies and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genotyping was performed in all children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and ten children were screened for coeliac disease, and coeliac disease could be confirmed in seven. Eighty\u2010six per\u00a0cent of the children with Type\u00a01 diabetes mellitus had one of the variants of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2.5 and <jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>8. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genotypes observed in children with Type\u00a01 diabetes mellitus children and coeliac disease were heterozygote <jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2.5, homozygote <jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2.5 and heterozygote <jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2.5\/<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>8. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genotyping in coeliac disease screening in children with Type\u00a01 diabetes mellitus is more expensive than screening for coeliac disease with antibodies alone (\u20ac326 vs. \u20ac182 per child).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of coeliac disease development in children with Type\u00a01 diabetes mellitus is increased when they are heterozygote <jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2.5\/<jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>8, homozygote or heterozygote <jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>2.5. The implementation of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genotyping as a first\u2010line screening tool has to be reconsidered because it is not distinctive or cost\u2010effective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12658","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T06:22:45Z","timestamp":1417760565000},"page":"834-838","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical relevance and cost\u2010effectiveness of <scp>HLA<\/scp> genotyping in children with Type 1 diabetes mellitus in screening for coeliac disease in the Netherlands"],"prefix":"10.1111","volume":"32","author":[{"given":"J.","family":"Elias","sequence":"first","affiliation":[{"name":"Department of Pediatrics St. Antonius Hospital Nieuwegein The Netherlands"},{"name":"Department of Cardiology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J. G.","family":"Hoorweg\u2010Nijman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. A.","family":"Balemans","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22123"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.6.532"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310000456"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200403000-00020"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31816de885"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/329599a0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1993.tb01998.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.4.491"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1999.0303"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.4.806"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.04.06.dc05-1923"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v2i4.151"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32834d09d4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02987.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2008.00367.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.4.850"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0921"},{"key":"e_1_2_8_20_1","first-page":"453","article-title":"Prevalence and clinical features of celiac disease in 950 children with type\u00a01 diabetes in France","volume":"33","author":"Poulian C","year":"2007","journal-title":"Diabetes Metab"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2009.00573.x"},{"key":"e_1_2_8_23_1","volume-title":"Kwaliteitsinstituut voor de Gezondheidszorg CBO","author":"Richtlijn Coeliakie en Dermatitis Herpetiformis","year":"2008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313977"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12658","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:29:31Z","timestamp":1696256971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,28]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/dme.12658"],"URL":"https:\/\/doi.org\/10.1111\/dme.12658","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,28]]},"assertion":[{"value":"2014-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}