{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:52:51Z","timestamp":1773111171217,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Competence Network Diabetes","award":["01GI1106"],"award-info":[{"award-number":["01GI1106"]}]},{"name":"Dr B\u00fcrger B\u00fcsing Stiftung"},{"name":"Experimental and Clinical Research Center"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Children and adolescents with a molecular diagnosis of HNF1A\u2013MODY should be treated with oral sulfonylurea according to current International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We surveyed the German\u2013Austrian DPV database of 50\u00a0043 people and included 114 patients with a confirmed molecular\u2013genetic diagnosis of HNF1A mutation and diabetes onset at below age 18\u00a0years. We analysed hypoglycaemic episodes, metabolic control (HbA\n                      <jats:sub>1c<\/jats:sub>\n                      ) and other clinical variables according to treatment groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      People with HNF1A\u2013MODY were included and analysed according to treatment with insulin alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a034), sulfonylurea (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030), meglitinides (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a022) or lifestyle (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a028). In those receiving any drug treatment (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a086), severe hypoglycaemia did not occur with meglitinide and was highest (at 3.6 events per 100 patient\u2010years) with insulin. HbA\n                      <jats:sub>1c<\/jats:sub>\n                      was highest with insulin treatment (insulin\u00a0=\u00a058\u00a0mmol\/mol, 7.5%; sulfonylurea\u00a0=\u00a055\u00a0mmol\/mol, 7.2%; meglitinides\u00a0=\u00a052\u00a0mmol\/mol, 6.9%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.008), whereas weight (BMI SD score), serum lipids and blood pressure were not different.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Of note, 40% of people with HNF1A\u2013MODY and medical treatment were receiving insulin alone and thus were not being treated in line with up\u2010to\u2010date International Society for Pediatric and Adolescent Diabetes\/International Diabetes Federation guidelines, despite insulin treatment being associated with worse metabolic control and the risk of hypoglycaemia. The unlicensed use of oral drugs in patients below age 18\u00a0years and adherence by both doctors and patients to the initial insulin treatment might contribute to this finding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.12662","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T23:25:24Z","timestamp":1418081124000},"page":"526-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Treatment of young patients with HNF1A mutations (HNF1A\u2013MODY)"],"prefix":"10.1111","volume":"32","author":[{"given":"K.","family":"Raile","sequence":"first","affiliation":[{"name":"Experimental and Clinical Research Center Charit\u00e9 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Schober","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Medical University of Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Konrad","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology and Diabetes Department of Paediatrics II University Children's Hospital Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Thon","sequence":"additional","affiliation":[{"name":"University Children's Hospital MHH Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Grulich\u2010Henn","sequence":"additional","affiliation":[{"name":"Children's Hospital University of Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Meissner","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics, Neonatology and Pediatric Cardiology University Children's Hospital D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"W\u00f6lfle","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology Division Children's Hospital University of Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Scheuing","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry University of Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.","family":"Holl","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry University of Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the DPV Initiative the German BMBF Competence Network Diabetes Mellitus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/384455a0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02720.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1279"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2621-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050931"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.4.726"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00305.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2009.00571.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2537"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2006.00217.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0842"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02690.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.4-2-144"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.8.1271"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.123224"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12662","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12662","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:28:59Z","timestamp":1696318139000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,30]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/dme.12662"],"URL":"https:\/\/doi.org\/10.1111\/dme.12662","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725520617.793507063","asserted-by":"object"}]},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,30]]},"assertion":[{"value":"2014-12-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}