{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:02:17Z","timestamp":1790935337978,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>A close association between heart rate\u2010corrected <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content> interval (<jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c) and albuminuria in people with Type\u00a02 diabetes has been reported in cross sectional studies. The aim of this study was to evaluate the relationship between <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c and change in urine albumin excretion (<jats:styled-content style=\"fixed-case\">UAE<\/jats:styled-content>) or progression of albuminuria in people with Type\u00a02 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c in 251 consecutive people at baseline. We performed a 5\u2010year follow\u2010up cohort study to assess the relationship between <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c and change in <jats:styled-content style=\"fixed-case\">UAE<\/jats:styled-content>, defined as an increase of <jats:styled-content style=\"fixed-case\">UAE<\/jats:styled-content>\/follow\u2010up duration (year), or progression of albuminuria, defined as an increase in the category of diabetic nephropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During follow\u2010up, 23 of 151 people with normoalbuminuria and 13 of 73 people with microalbuminuria at baseline had progression of albuminuria. Multiple regression analysis demonstrated that <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c was independently associated with change in <jats:styled-content style=\"fixed-case\">UAE<\/jats:styled-content> (\u03b2\u00a0=\u00a00.176, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0104<jats:italic>)<\/jats:italic>. Logistic regression analyses showed that <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c was a risk marker for progression of albuminuria [odds ratio per 0.01\u2010s increase in <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c 1.35, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.11\u20131.66, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0024] after adjusting for confounders. According to the receiver operator characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) analysis, the optimal cut\u2010off point of <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c for progression of albuminuria was 0.418\u00a0s [area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve 0.75 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.66\u20130.82), sensitivity\u00a0=\u00a00.86, specificity\u00a0=\u00a00.56, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Heart rate\u2010corrected <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content> interval could be a novel risk marker for progression of albuminuria in people with Type\u00a02 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12728","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T11:24:23Z","timestamp":1423826663000},"page":"1221-1226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Heart rate\u2010corrected <scp>QT<\/scp> interval is a novel risk marker for the progression of albuminuria in people with Type\u00a02 diabetes"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-0550","authenticated-orcid":false,"given":"Y.","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine Graduate School of Medical Science Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyoto Prefectural 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