{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:29:15Z","timestamp":1785796155049,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:00:00Z","timestamp":1433980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Center for Diabetes Research (DZD)","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the hypothesis that high serum levels of omentin, an adipokine with anti\u2010inflammatory, insulin\u2010sensitizing and cardioprotective properties, may be related to a lower risk of diabetic sensorimotor polyneuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The association between serum omentin level and polyneuropathy was estimated in people aged 61\u201382\u00a0years with Type 2 diabetes (47 with and 168 without polyneuropathy) from the population\u2010based <jats:styled-content style=\"fixed-case\">KORA<\/jats:styled-content> F4 study. The presence of clinical diabetic sensorimotor polyneuropathy was defined as bilateral impairment of foot vibration perception and\/or foot pressure sensation. Omentin levels were determined by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum omentin level was inversely associated with polyneuropathy after adjustment for age, sex, height, waist circumference, hypertension, total cholesterol, smoking, alcohol intake and physical activity [odds ratio 0.45 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.21\u20130.98); <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.043]. Although omentin was positively correlated with adiponectin (r\u00a0=\u00a00.55, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001) and inversely with tumour necrosis factor\u2010\u03b1 (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>\u20100.30, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.019), additional adjustment for adiponectin and tumour necrosis factor\u2010\u03b1 had little impact on the association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum levels of omentin are reduced in people with Type 2 diabetes and diabetic sensorimotor polyneuropathy, independently of established risk factors of polyneuropathy. This association is only partially explained by biomarkers of subclinical inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12761","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T22:39:02Z","timestamp":1434753542000},"page":"1479-1483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Low serum omentin levels in the elderly population with Type 2 diabetes and polyneuropathy"],"prefix":"10.1111","volume":"32","author":[{"given":"C.","family":"Herder","sequence":"first","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Centre Leibniz Centre for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"German Centre for Diabetes Research (DZD e.V.) Partner D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W. C.","family":"Bongaerts","sequence":"additional","affiliation":[{"name":"Institute for Biometrics and Epidemiology German Diabetes Centre Leibniz Centre for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Ouwens","sequence":"additional","affiliation":[{"name":"German Centre for Diabetes Research (DZD e.V.) Partner D\u00fcsseldorf Germany"},{"name":"Institute of Clinical Biochemistry and Pathobiochemistry German Diabetes Centre Leibniz Centre for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"Department of Endocrinology Ghent University Hospital Ghent Belgium Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Rathmann","sequence":"additional","affiliation":[{"name":"Institute for Biometrics and Epidemiology German Diabetes Centre Leibniz Centre for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Heier","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II Helmholtz Zentrum M\u00fcnchen German Research Centre for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Carstensen\u2010Kirberg","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Centre Leibniz Centre for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"German Centre for Diabetes Research (DZD e.V.) Partner D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II \u2013 Cardiology University of Ulm Medical Center Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Thorand","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II Helmholtz Zentrum M\u00fcnchen German Research Centre for Environmental Health Neuherberg Germany"},{"name":"German Centre for Diabetes Research (DZD e.V.) Partner Neuherberg Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Roden","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Centre Leibniz Centre for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"German Centre for Diabetes Research (DZD e.V.) Partner D\u00fcsseldorf Germany"},{"name":"Department of Endocrinology and Diabetology Medical Faculty, Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Meisinger","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II Helmholtz Zentrum M\u00fcnchen German Research Centre for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Centre Leibniz Centre for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"German Centre for Diabetes Research (DZD e.V.) Partner D\u00fcsseldorf Germany"},{"name":"Department of Endocrinology and Diabetology Medical Faculty, Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the KORA Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1964"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00572.2004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.04.039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059697"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.032"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02863.x"},{"key":"e_1_2_9_8_1","volume-title":"Report of a WHO Consultation: Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications","author":"World Health Organisation","year":"1999"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2028"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0879"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0382"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12155"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvt073"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0215"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0740"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-014-0537-6"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-014-0601-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2385"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06417.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/878760"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12761","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:10:55Z","timestamp":1696367455000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,11]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/dme.12761"],"URL":"https:\/\/doi.org\/10.1111\/dme.12761","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,11]]},"assertion":[{"value":"2015-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}