{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:49:15Z","timestamp":1767649755930},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,4,12]],"date-time":"2015-04-12T00:00:00Z","timestamp":1428796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIHR Collaboration for Leadership in Applied Health Research and Care East Midlands"},{"name":"NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit"},{"name":"Novartis Pharmaceuticals"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether previous physical activity levels are associated with blood glucose levels in individuals with impaired glucose tolerance in the context of an international pharmaceutical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were analysed from the <jats:styled-content style=\"fixed-case\">NAVIGATOR<\/jats:styled-content> trial, which involved 9306 individuals with impaired glucose tolerance and high cardiovascular risk from 40 different countries, recruited in the period 2002\u20132004. Fasting glucose, 2\u2010h post\u2010challenge glucose and physical activity (pedometer) were assessed annually. A longitudinal regression analysis was used to determine whether physical activity levels 2\u00a0years (t<jats:sub>\u20102<\/jats:sub>) and 1\u00a0year (t<jats:sub>\u20101<\/jats:sub>) previously were associated with\u00a0levels of glucose, after adjusting for previous glucose levels and other patient characteristics. Those participants with four consecutive annual measures of glucose and two consecutive measures of physical activity were included in the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 3964 individuals. Change in physical activity from t<jats:sub>\u20102<\/jats:sub> to t<jats:sub>\u20101<\/jats:sub> and activity levels at t<jats:sub>\u20102<\/jats:sub> were both associated with 2\u2010h glucose levels after adjustment for previous glucose levels and baseline characteristics; however, the associations were weak: a 100% increase in physical activity was associated with a 0.9% reduction in 2\u2010h glucose levels. In addition, previous physical activity only explained an additional 0.05% of the variance in 2\u2010h glucose over the variance explained by the history of 2\u2010h glucose alone (R<jats:sup>2<\/jats:sup>\u00a0=\u00a00.3473 vs. 0.3468). There was no association with fasting glucose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the context of a large international clinical trial, previous physical activity levels did not meaningfully influence glucose levels in those with a high risk of chronic disease, after taking into account participants' previous trajectory of glucose control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12762","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T22:30:53Z","timestamp":1427495453000},"page":"1090-1096","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Physical activity as a determinant of fasting and 2\u2010h post\u2010challenge glucose: a prospective cohort analysis of the <scp>NAVIGATOR<\/scp> trial"],"prefix":"10.1111","volume":"32","author":[{"given":"T.","family":"Yates","sequence":"first","affiliation":[{"name":"NIHR Leicester\u2010Loughborough Diet Lifestyle, and Physical Activity Biomedical Research Unit Leicester UK"},{"name":"Diabetes Research Centre College of Medicine Biological Sciences and Psychology University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Davies","sequence":"additional","affiliation":[{"name":"NIHR Leicester\u2010Loughborough Diet Lifestyle, and Physical Activity Biomedical Research Unit Leicester UK"},{"name":"Diabetes Research Centre College of Medicine Biological Sciences and Psychology University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Haffner","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Texas Health Science Center San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Schulte","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Huffman","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"Bales","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC USA"},{"name":"Durham VA Medical Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Preiss","sequence":"additional","affiliation":[{"name":"British Heart Foundation Glasgow Cardiovascular Research Centre University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Califf","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"Holman","sequence":"additional","affiliation":[{"name":"Diabetes Trials Unit University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J. V.","family":"McMurray","sequence":"additional","affiliation":[{"name":"British Heart Foundation Glasgow Cardiovascular Research Centre University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Bethel","sequence":"additional","affiliation":[{"name":"Diabetes Trials Unit University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tuomilehto","sequence":"additional","affiliation":[{"name":"Centre for Vascular Prevention Danube University Krems Krems Austria"},{"name":"South Ostrobothnia Central Hospital Seinajoki Finland"},{"name":"King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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