{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T21:54:50Z","timestamp":1721944490479},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T00:00:00Z","timestamp":1431043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["129293"],"award-info":[{"award-number":["129293"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine changes in glucose metabolism (fasting and 2\u2010h glucose) during follow\u2010up in people with impaired fasting glucose in comparison with changes in people with isolated impaired glucose tolerance, people with impaired fasting glucose and impaired glucose tolerance combined and people with screening\u2010detected Type 2 diabetes at baseline, among those who participated in a diabetes prevention programme conducted in Finland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 10\u00a0149 people at high risk of Type 2 diabetes took part in baseline examination. Of 5351 individuals with follow\u2010up \u2265\u00a09\u00a0months, 1727 had impaired glucose metabolism at baseline and completed at least one lifestyle intervention visit. Most of them (94.6%) were overweight\/ obese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fasting glucose decreased during follow\u2010up among overweight\/obese people in the combined impaired fasting glucose and impaired glucose tolerance group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.044), as did 2\u2010h glucose in people in the isolated impaired glucose tolerance group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0014) after adjustment for age, sex, medication and weight at baseline, follow\u2010up time and changes in weight, physical activity and diet. When comparing changes in glucose metabolism among people with different degrees of glucose metabolism impairment, fasting glucose concentration was found to have increased in those with isolated impaired glucose tolerance (0.12\u00a0mmol\/l, 95% Cl 0.05 to 0.19) and it decreased to a greater extent in those with screening\u2010detected Type 2 diabetes (\u22120.54\u00a0mmol\/l, 95% Cl \u22120.69 to \u22120.39) compared with those with impaired fasting glucose (\u22120.21\u00a0mmol\/l, 95% Cl \u22120.27 to \u22120.15). Furthermore, 2\u2010h glucose concentration decreased in the isolated impaired glucose tolerance group (\u22120.82\u00a0mmol\/l, 95% Cl \u22121.04 to \u22120.60), in the combined impaired fasting glucose and impaired glucose tolerance group (\u22120.82\u00a0mmol\/l, 95% Cl \u22121.07 to \u22120.58) and in the screening\u2010detected Type 2 diabetes group (\u22121.52, 95% Cl \u22121.96 to \u22121.08) compared with those in the impaired fasting glucose group (0.26\u00a0mmol\/l, 95% Cl 0.10 to 0.43). Results were statistically significant even after adjustment for covariates (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001 in all models).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Changes in glucose metabolism differ in people with impaired fasting glucose from those in people with isolated impaired glucose tolerance, people with impaired fasting glucose and impaired glucose tolerance combined and people with screening\u2010detected Type 2 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12776","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T23:22:25Z","timestamp":1428708145000},"page":"1611-1616","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in glucose metabolism in people with different glucose metabolism disorders at baseline: follow\u2010up results of a Finnish national diabetes prevention programme"],"prefix":"10.1111","volume":"32","author":[{"given":"N.","family":"Rautio","sequence":"first","affiliation":[{"name":"Institute of Health Sciences University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jokelainen","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences University of Oulu Oulu Finland"},{"name":"Unit of General Practice Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Oksa","sequence":"additional","affiliation":[{"name":"Pirkanmaa Hospital District Pirkanmaa Hospital District Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Saaristo","sequence":"additional","affiliation":[{"name":"Pirkanmaa Hospital District Pirkanmaa Hospital District Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Peltonen","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Puolijoki","sequence":"additional","affiliation":[{"name":"South Ostrobothnia Hospital District Sein\u00e4joki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tuomilehto","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare Helsinki Finland"},{"name":"Centre for Vascular Prevention Danube\u2010University Krems Krems Austria"},{"name":"Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ) Madrid Spain"},{"name":"King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vanhala","sequence":"additional","affiliation":[{"name":"Unit of Family Practice Central Finland Hospital District, Jyv\u00e4skyl\u00e4, Kuopio University Hospital, and University of Eastern Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Moilanen","sequence":"additional","affiliation":[{"name":"Department of Medicine Kuopio University Hospital Northern Savo Hospital District Kuopio campus Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Uusitupa","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio campus Kuopio Finland"},{"name":"Research Unit Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kein\u00e4nen\u2010Kiukaanniemi","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences University of Oulu Oulu Finland"},{"name":"Unit of Primary Health Care Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441801"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2004.06.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0097-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.4.537"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012512"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.275"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01608.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3402\/ijch.v66i2.18239"},{"key":"e_1_2_8_10_1","unstructured":"The Finnish Diabetes Association.Implementation of Type 2 Diabetes Prevention Plan. 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