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Med."],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore the role of early pregnancy health\u2010related quality of life, anxiety, depression and locus of control for pregnancy outcome in women with pregestational diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cohort study of 148 pregnant women with pregestational diabetes (118 with Type 1 diabetes and 30 with Type 2 diabetes), who completed three internationally validated questionnaires: the 36\u2010item Short\u2010Form Health Survey, the Hospital Anxiety and Depression Scale and the Multidimensional Health Locus of Control survey at 8\u00a0weeks. Selected pregnancy outcomes were preterm delivery (&lt;\u00a037\u00a0weeks) and large for gestational age infants (birth weight &gt;\u00a090<jats:sup>th<\/jats:sup> percentile). Differences between groups in the questionnaires were analysed using an unpaired <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with preterm deliveries (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>28) had lower (i.e. worse) mean (<jats:sc>sd<\/jats:sc>) quality\u2010of\u2010life scores for the two 36\u2010item Short\u2010Form Health Survey scales, Role\u2010Emotional [58.3 (38.1) vs. 82.9 (31.3); <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0005] and Mental Health [67.7 (20.4) vs. 75.2 (15.8), <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04], and a lower score for the 36\u2010item Short\u2010Form Health Survey scale Mental Component Summary (42.8 (13.1) vs. 48.8 (9.7), <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03) in early pregnancy, compared with women with term deliveries. Depression symptoms (Hospital Anxiety and Depression Scale depression score \u2265\u00a08) were more frequent in women with preterm vs. term deliveries (seven (25%) vs. six women (5%); <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003), while levels of anxiety and locus of control were similar in these two groups. No difference in early pregnancy scores for health\u2010related quality of life, anxiety, depression and locus of control were seen in women delivering large or appropriate for gestational age infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Poor mental quality of life and the presence of depressive symptoms in early pregnancy were associated with preterm delivery in women with pregestational diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12777","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T23:09:15Z","timestamp":1428707355000},"page":"1484-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mental health in early pregnancy is associated with pregnancy outcome in women with pregestational diabetes"],"prefix":"10.1111","volume":"32","author":[{"given":"N. F.","family":"Callesen","sequence":"first","affiliation":[{"name":"Center for Pregnant Women with Diabetes Rigshospitalet Copenhagen Denmark"},{"name":"Department of Endocrinology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Secher","sequence":"additional","affiliation":[{"name":"Center for Pregnant Women with Diabetes Rigshospitalet Copenhagen Denmark"},{"name":"Department of Endocrinology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Cramon","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ringholm","sequence":"additional","affiliation":[{"name":"Center for Pregnant Women with Diabetes Rigshospitalet Copenhagen Denmark"},{"name":"Department of Endocrinology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Watt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Damm","sequence":"additional","affiliation":[{"name":"Center for Pregnant Women with Diabetes Rigshospitalet Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Obstetrics Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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