{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:26:38Z","timestamp":1780395998008,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the renal effects of fitness in people with diabetes with mild renal dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The effect of a 12\u2010week exercise programme on estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> in 128 people with diabetes was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All cardiometabolic variables improved after 12\u00a0weeks of supervised exercise. Although there was a modest 3.9% increase in estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> from baseline in the 128 people who completed the study, those with baseline chronic kidney disease stages 2 and 3 were found to have significant (6 and 12%, respectively; p\u00a0&lt;\u00a00.01) improvements in post\u2010exercise estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>. Moreover, 42% of the people with chronic kidney disease stage 3 improved to chronic kidney disease stage 2 after the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Short\u2010term exercise improves renal function in those with more moderate baseline chronic kidney disease. Thus, renal function appears to be responsive to enhanced physical fitness. Being a strong and modifiable risk factor, enhanced fitness should be considered a non\u2010pharmacological adjunct in the management of diabetic kidney disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12789","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T07:09:31Z","timestamp":1430896171000},"page":"1342-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Enhanced fitness and renal function in Type 2 diabetes"],"prefix":"10.1111","volume":"32","author":[{"given":"E. S.","family":"Nylen","sequence":"first","affiliation":[{"name":"Department of Endocrinology Veterans Affairs Medical Center Washington DC USA"},{"name":"Department of Endocrinology George Washington University School of Medicine and Health Sciences Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Veterans Affairs Medical Center Washington DC USA"},{"name":"Department of Endocrinology George Washington University School of Medicine and Health Sciences Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kheirbek","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Veterans Affairs Medical Center Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kokkinos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Veterans Affairs Medical Center Washington DC USA"},{"name":"Department of Cardiology George Washington University School of Medicine and Health Sciences Washington DC USA"},{"name":"Department of Cardiology Georgetown University School of Medicine Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.861"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.296"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310799"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011858"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1876"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.3.1003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.28608B"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90051-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000189497"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.03.020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040392"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12285"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31820c0130"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.02.337"},{"key":"e_1_2_7_17_1","first-page":"1","article-title":"KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"3","author":"Kidney Disease: Improving Global outcomes (KDIGO) CKD Work Group","year":"2013","journal-title":"Kid Int"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319593"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft529"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.10.008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13031213"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12789","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:26:57Z","timestamp":1696292817000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,28]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/dme.12789"],"URL":"https:\/\/doi.org\/10.1111\/dme.12789","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,28]]},"assertion":[{"value":"2015-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}