{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:48:32Z","timestamp":1759178912928},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Centres for Disease Control and Prevention","award":["2006-347-2400-2440-215","2008-E71004-00","2009-E71006-00","2010-E71003-00","2011-E71002-00","2012-E71007-00","2013-E71008-00"],"award-info":[{"award-number":["2006-347-2400-2440-215","2008-E71004-00","2009-E71006-00","2010-E71003-00","2011-E71002-00","2012-E71007-00","2013-E71008-00"]}]},{"name":"Korean Health Technology R&D Project, Ministry of Health & Welfare","award":["HI13C0715"],"award-info":[{"award-number":["HI13C0715"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the performance of HbA<jats:sub>1c<\/jats:sub> in predicting incident diabetes among Korean adults with normal fasting glucose and impaired fasting glucose levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study used data from the Korean Genome Epidemiology Study\u2010Kangwha Study. A prospective analysis was carried out on 2079 people (820 men and 1259 women) who completed follow\u2010up examinations up until 2013. Diabetes was defined as fasting blood glucose level \u2265\u00a07.0\u00a0mmol\/l, HbA<jats:sub>1c<\/jats:sub> level \u2265\u00a048\u00a0mmol\/mol (6.5%), or current treatment for diabetes. Areas under the receiver\u2010operating characteristic curves were used to assess the different performances of HbA<jats:sub>1c<\/jats:sub>, glucose and insulin in predicting diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time was 3.97\u00a0years, during which 7.7% of men and 6.3% of women developed incident diabetes. The areas under the receiver\u2010operating curves (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) for diabetes prediction were 0.740 (0.692\u20130.787) for HbA<jats:sub>1c<\/jats:sub>, 0.716 (0.667\u20130.764) for glucose and 0.598 (0.549\u20130.648) for insulin. HbA<jats:sub>1c<\/jats:sub> showed better predictive power in people with impaired fasting glucose (area under the curve 0.753, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.685\u20130.821) than in those with normal glucose (area under the curve 0.648, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.577\u20130.719). An HbA<jats:sub>1c<\/jats:sub> threshold of 40\u00a0mmol\/mol (5.8%) was found to have the highest predictive value for diabetes, with a relative risk of 6.30 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.49\u201311.35) in men and 3.52 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.06\u20136.03) in women after adjusting for age, waist circumference, triglycerides, hypertension, family history of diabetes, smoking, alcohol intake, exercise and baseline glucose level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HbA<jats:sub>1c<\/jats:sub> can be used to identify people at high risk for the development of diabetes, especially in those with impaired fasting glucose levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12794","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T04:50:55Z","timestamp":1431406255000},"page":"1602-1610","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Performance of HbA<sub>1c<\/sub> for the prediction of diabetes in a rural community in Korea"],"prefix":"10.1111","volume":"32","author":[{"given":"B. M.","family":"Song","sequence":"first","affiliation":[{"name":"Department of Public Health Ajou University School of Medicine Suwon Korea"},{"name":"Cardiovascular and Metabolic Disease Aetiology Research Centre Ajou University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. C.","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Disease Aetiology Research Centre Ajou University School of Medicine Suwon Korea"},{"name":"Department of Preventive Medicine Ajou University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Disease Aetiology Research Centre Ajou University School of Medicine Suwon Korea"},{"name":"Department of Endocrinology and Metabolism Ajou University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Ajou University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60679-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.9.1414"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-380"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1360-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0803-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.3.436"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-6-200409210-00006"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"S62","volume":"33","author":"Diagnosis and classification of diabetes mellitus","year":"2010","journal-title":"Diabetes Care"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2012.36.1.37"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03634.x"},{"key":"e_1_2_9_13_1","first-page":"835","article-title":"Glycated hemoglobin in diagnosis of diabetes mellitus and pre\u2010diabetes; validation by oral glucose tolerance test. 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