{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:54:30Z","timestamp":1790384070079,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research (CIHR)","doi-asserted-by":"crossref","award":["MOP#123263"],"award-info":[{"award-number":["MOP#123263"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ontario Institute for Cancer Research"},{"DOI":"10.13039\/100009142","name":"Cancer Care Ontario","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009142","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012665","name":"Institute for Clinical Evaluative Sciences (ICES)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long-Term Care (MOHLTC)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the relationship between gestational diabetes (GDM) and incidence of cancer in women within the first decade postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This population\u2010based retrospective cohort study compared the risk of cancer in women with GDM with that of a matched control group comprising pregnant women without diabetes. We included women from Ontario, Canada aged 20\u201350\u00a0years with no history of cancer who had given birth between 1995 and 2008 (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>149 049). Women with GDM (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>49 684) were matched on age and year of giving birth, in a ratio of 1:2, to pregnant women without diabetes (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>99 365).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a median 8\u2010year follow\u2010up, there were a total of 2927 (1.5%) cancers. After adjustment for covariates, we found no significant difference in overall risk of cancer between women with GDM and matched control subjects; however, GDM was associated with a significantly greater risk of thyroid cancer (adjusted hazard ratio 1.24, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.05, 1.46) and a significantly lower risk of premenopausal breast cancer (hazard ratio 0.86, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.75, 0.98) compared with matched control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This large population\u2010based study did not find a greater risk of cancers among women with GDM during the first decade postpartum; however, GDM was associated with a higher risk of thyroid cancer and a lower risk of premenopausal breast cancer. Further studies are needed to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12796","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T12:58:25Z","timestamp":1431521905000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Short\u2010term risk of cancer among women with previous gestational diabetes: a population\u2010based study"],"prefix":"10.1111","volume":"33","author":[{"given":"S. A. D.","family":"Bejaimal","sequence":"first","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. F.","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"},{"name":"Sunnybrook Health Sciences Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. S.","family":"Feig","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"},{"name":"Institute for Clinical Evaluative Sciences Toronto ON Canada"},{"name":"Mount Sinai Hospital Toronto ON Canada"},{"name":"Institute of Health Policy Management and Evaluation University of Toronto Toronto ON Canada"},{"name":"Department of Obstetrics and Gynecology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. R.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"},{"name":"Institute for Clinical Evaluative Sciences Toronto ON Canada"},{"name":"Sunnybrook Health Sciences Centre Toronto ON Canada"},{"name":"Institute of Health Policy Management and Evaluation University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. L.","family":"Lipscombe","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"},{"name":"Institute for Clinical Evaluative Sciences Toronto ON Canada"},{"name":"Institute of Health Policy Management and Evaluation University of Toronto Toronto ON Canada"},{"name":"Women's College Research Institute Women's College Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP10357.RA"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-09-0087"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090399"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9166-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32836162aa"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0351"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0706"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1363"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60731-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20013"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.19.2474"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-5-25"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9585-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9825-5"},{"key":"e_1_2_9_17_1","volume-title":"Canadian Cancer Statistics 2014","author":"Canadian Cancer Society's Advisory Committee on Cancer Statistics","year":"2014"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.18.2090"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.512"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90052-2"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"S1","article-title":"2008 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada","volume":"32","author":"Canadian Diabetes Association Clinical Practice Guidelines Expert Committee","year":"2008","journal-title":"Can J Diabetes"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22717"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0396"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-9896-y"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0207-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.08.009"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2307\/3434174"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/578285"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.6.514"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2009.172890"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2525-1"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2717"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12796","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:08:28Z","timestamp":1696331308000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,15]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/dme.12796"],"URL":"https:\/\/doi.org\/10.1111\/dme.12796","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,15]]},"assertion":[{"value":"2015-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}