{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:24:27Z","timestamp":1780658667712,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001825","name":"Styrelsen for Forskning og Innovation","doi-asserted-by":"publisher","award":["09\u2010067009"],"award-info":[{"award-number":["09\u2010067009"]}],"id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001825","name":"Styrelsen for Forskning og Innovation","doi-asserted-by":"publisher","award":["09\u2010075724"],"award-info":[{"award-number":["09\u2010075724"]}],"id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007324","name":"Sundhedsstyrelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine prescribing practices and predictors of glucose\u2010lowering therapy within the first year following diagnosis of Type\u00a02 diabetes mellitus in a clinical care setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed people enrolled in the Danish Centre for Strategic Research in Type\u00a02 Diabetes (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>2) cohort from outpatient hospital clinics and general practices throughout Denmark in 2010\u20132013. We used Poisson regression to compute age\u2010 and gender\u2010adjusted risk ratios (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1158 new Type\u00a02 diabetes mellitus patients, 302 (26%) did not receive glucose\u2010lowering therapy within the first year, 723 (62%) received monotherapy [685 (95%) with metformin], and 133 (12%) received more than one drug. Predictors of receiving any vs. no therapy and combination vs. monotherapy were: age &lt;\u00a040\u00a0years [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>: 1.29 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.16\u20131.44) and 3.60 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.36\u20135.50)]; high Charlson Comorbidity Index [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>s: 1.20 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.05\u20131.38) and 2.08 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.16\u20133.72)]; central obesity [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>s: 1.23 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.04\u20131.44) and 1.93 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.76\u20134.94)]; fasting blood glucose of \u2265\u00a07.5\u00a0mmol\/l [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>s: 1.25 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.10\u20131.42) and 1.94 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.02\u20133.71)]; and HbA<jats:sub>1c<\/jats:sub>\u00a0\u2265\u00a059\u00a0mmol\/mol (\u2265\u00a07.5%) [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>: 1.26 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.20\u20131.32) and 2.86 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.97\u20134.14)]. Weight gain \u2265\u00a030\u00a0kg since age 20, lack of physical exercise and C\u2013peptide of &lt;\u00a0300\u00a0pmol\/l also predicted therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Comorbidity, young age, central obesity and poor baseline glycaemic control are important predictors of therapy one year after Type\u00a02 diabetes mellitus debut.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12819","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T08:26:04Z","timestamp":1433147164000},"page":"1546-1554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Prescribing practices and clinical predictors of glucose\u2010lowering therapy within the first year in people with newly diagnosed Type\u00a02 diabetes"],"prefix":"10.1111","volume":"32","author":[{"given":"A.","family":"Mor","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Berencsi","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rungby","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University Hospital Aarhus Denmark"},{"name":"Center for Diabetes Research Gentofte University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Friborg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Brandslund","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Lillebaelt Hospital Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrinology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vaag","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Rigshospitalet and Copenhagen University Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Beck\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. T.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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