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Med."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate C\u2013reactive protein, insulin growth factor\u00a01 and lipid levels during the follicular and luteal phases in adolescents with Type\u00a01 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adolescents with Type\u00a01 diabetes (<jats:italic>N<\/jats:italic>\u00a0=\u00a040) and healthy controls (C; <jats:italic>N<\/jats:italic>\u00a0=\u00a043) were studied during the follicular and luteal phases of their menstrual cycles. C\u2013Reactive protein, insulin growth factor\u00a01 and lipid levels were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adolescents with Type\u00a01 diabetes exhibited higher C\u2013reactive protein levels than the C\u00a0group during the follicular (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and luteal phases (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). The elevation of C\u2013reactive protein levels was more pronounced in overweight adolescents with Type\u00a01 diabetes than in adolescents in the C\u00a0group. More adolescents with Type\u00a01 diabetes were classified as having an elevated risk of cardiovascular disease (C\u2013reactive protein\u00a0&gt;\u00a03\u00a0mg\/l) in the luteal phase than in the follicular phase (37.5% and 17.5%, respectively); half of the overweight adolescents with Type\u00a01 diabetes in the luteal phase reached this level. <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was the only significant factor affecting follicular and luteal phase C\u2013reactive protein levels in adolescents with Type\u00a01 diabetes. Lower insulin growth factor\u00a01 levels were observed during both phases of the menstrual cycle in adolescents with Type\u00a01 diabetes compared with controls. An elevation in insulin growth factor\u00a01 levels in the luteal phase relative to the follicular phase was observed in controls, but not in adolescents with Type\u00a01 diabetes. Luteal insulin growth factor\u00a01 and C\u2013reactive protein exhibited an inverse correlation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u20130.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adolescents with Type\u00a01 diabetes have higher C\u2013reactive protein levels and lower insulin growth factor\u00a01 levels relative to controls, especially during the luteal phase. Type\u00a01 diabetes diminishes the natural elevation in insulin growth factor\u00a01 levels observed during the luteal phase in controls. Excess weight exacerbates the subclinical inflammatory state observed during both phases of the menstrual cycle in adolescents with Type\u00a01 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12829","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T15:35:04Z","timestamp":1433432104000},"page":"70-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["C\u2010Reactive protein and insulin growth factor\u00a01 serum levels during the menstrual cycle in adolescents with Type 1 diabetes"],"prefix":"10.1111","volume":"33","author":[{"given":"E.","family":"Codner","sequence":"first","affiliation":[{"name":"Institute of Maternal and Child Research University of Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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