{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:43:37Z","timestamp":1789983817774,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess resource utilization associated with severe hypoglycaemia across three insulin regimens in a large phase\u00a03a clinical programme involving people with Type\u00a01 diabetes treated with basal\u2013bolus insulin, people with Type\u00a02 diabetes treated with multiple daily injections and people with Type\u00a02 diabetes treated with basal\u2013oral therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data relating to severe hypoglycaemia events (defined as episodes requiring external assistance) from the insulin degludec and insulin degludec\/insulin aspart programme (15 trials) were analysed using descriptive statistics. Comparators included insulin glargine, biphasic insulin aspart, insulin detemir and sitagliptin. Mealtime insulin aspart was used in some regimens. This analysis used the serious adverse events records, which documented the use of ambulance\/emergency teams, a hospital\/emergency room visit \u2264\u00a024\u00a0h, or a hospital visit &gt;\u00a024\u00a0h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 536 severe hypoglycaemia events were analysed, of which 157 (29.3%) involved an ambulance\/emergency team, 64 (11.9%) led to hospital\/emergency room attendance of \u2264\u00a024\u00a0h and 36 (6.7%) required hospital admission (&gt;\u00a024\u00a0h). Although there were fewer events in people with Type\u00a02 diabetes compared with Type\u00a01 diabetes, once a severe episode occurred, the tendency to utilize healthcare resources was higher in Type\u00a02 diabetes vs. Type\u00a01 diabetes. A higher proportion (47.6%) in the basal\u2013oral therapy group required hospital treatment for &gt;\u00a024\u00a0h versus the Type\u00a01 diabetes (5.0%) and Type\u00a02 diabetes multiple daily injections (5.3%) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This analysis suggests that severe hypoglycaemia events often result in emergency\/ambulance calls and hospital treatment, incurring a substantial health economic burden, and were associated with all insulin regimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12844","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T05:22:39Z","timestamp":1437024159000},"page":"471-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Severe hypoglycaemia in adults with insulin\u2010treated diabetes: impact on healthcare resources"],"prefix":"10.1111","volume":"33","author":[{"given":"S. R.","family":"Heller","sequence":"first","affiliation":[{"name":"Academic Unit of Diabetes, Endocrinology and Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M.","family":"Frier","sequence":"additional","affiliation":[{"name":"The Queen's Medical Research Institute University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Hersl\u00f8v","sequence":"additional","affiliation":[{"name":"Medical &amp; Science Novo Nordisk A\/S S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gundgaard","sequence":"additional","affiliation":[{"name":"Health Economics &amp; HTA Novo Nordisk A\/S S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C. L.","family":"Gough","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes Endocrinology and Metabolism Academic Health Science Network NIHR Oxford Biomedical Research Centre University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01880.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01501.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0599-y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(10)70470-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.796"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S46805"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1993.tb00051.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.10.046"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2011.02.001"},{"key":"e_1_2_11_11_1","first-page":"186","article-title":"Assessment of the impact of fear of hypoglycemic episodes on glycemic and hypoglycemic management","volume":"29","author":"Leiter LA","year":"2005","journal-title":"Can J Diabetes"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-6-73"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-005-0276-3"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00883.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-90"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696990903336597"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.4.1176"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.1.220"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1103053"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.136"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1241823"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.1824"},{"key":"e_1_2_11_23_1","first-page":"199","article-title":"ICH Harmonised Tripartite Guideline: guideline for good clinical practice","volume":"47","author":"International Conference on Harmonisation","year":"2001","journal-title":"J Postgrad Med"},{"key":"e_1_2_11_24_1","first-page":"403","article-title":"Declaration of Helsinki. Ethical principles for medical research involving human subjects","volume":"107","author":"World Medical Association","year":"2009","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60204-9"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3249"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12298"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2503"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60205-0"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2908"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.09.026"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2329"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1205"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12102"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1668"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12115"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12097"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.19.2563"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.405"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118695432"},{"key":"e_1_2_11_42_1","first-page":"33.1","volume-title":"Textbook of Diabetes","author":"Heller SR","year":"2003"},{"key":"e_1_2_11_43_1","unstructured":"UK National Health Service.UK Tariffs for Admitted Patient Care & Outpatient Procedures \u2010 Diabetes with Hypoglycaemia Disorder 2014. Available athttps:\/\/www.gov.uk\/government\/publications\/payment-by-results-pbr-operational-guidance-and-tariffsLast accessed June 2014."},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696990903310501"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta14360"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2013.08.653"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-2671(07)11008-X"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12844","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12844","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:50:51Z","timestamp":1696362651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,16]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/dme.12844"],"URL":"https:\/\/doi.org\/10.1111\/dme.12844","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,16]]},"assertion":[{"value":"2015-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}