{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:17:20Z","timestamp":1790713040687,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess whether diabetes increases the risk of carpal tunnel syndrome and to estimate the magnitude of the association with Type 1 and Type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic search of PubMed, Embase, Web of Science, Scopus, Google Scholar and ResearchGate for articles published between 1950 and January 2015. A total of 36 studies (eight cross\u2010sectional, 21 case\u2013control and seven cohort studies) qualified for meta\u2010analysis. We used a random\u2010effects meta\u2010analysis and assessed heterogeneity and publication bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The pooled odds ratio of 25 studies (including a total of 92 564 individuals) that reported unadjusted estimates for the association between diabetes and carpal tunnel syndrome or carpal tunnel release was 1.97 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.56\u20132.49). The pooled odds ratio of 18 case\u2013control or cohort studies consisting of &gt;37 million individuals that reported estimates after controlling for potential confounders was 1.69 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.45\u20131.96). The association did not differ for Type 1 and Type 2 diabetes. Furthermore, there was no publication bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta\u2010analysis suggests that both Type 1 and Type 2 diabetes are risk factors for carpal tunnel syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.12855","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T17:33:28Z","timestamp":1436895208000},"page":"10-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":167,"title":["Diabetes as a risk factor for carpal tunnel syndrome: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"M. 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