{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:41:12Z","timestamp":1776793272538,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL071739"],"award-info":[{"award-number":["R01 HL071739"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The metabolic syndrome (MetS) is a clustering of low levels of <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol, hyperglycaemia, high waist circumference, hypertension and elevated triglycerides, and is associated with cardiovascular disease. Calcified atherosclerotic plaque in the thoracic aorta (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>), measured by non\u2010contrast cardiac computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) scans, is a marker for atherosclerosis and relates to mortality. We sought to evaluate the independent association of MetS and <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> on cardiac <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the relation of the MetS, and each of its components, to the prevalence of <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>, measured from 2000 to 2002 in 6778 white, Chinese, African\u2010American and Hispanic participants in the Multi\u2010Ethnic Study of Atherosclerosis (<jats:styled-content style=\"fixed-case\">MESA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adjusting for age, gender, race, smoking, <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> cholesterol and lipid\u2010lowering medications, relative risks and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) for a <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> score &gt; 0 were: 1.19 (95% CI 1.11 to 1.28) for participants with MetS, 1.34 (95% CI 1.21 to 1.49) for those with diabetes and MetS, and 1.33 (95% CI 1.11, 1.58) for those with diabetes and no MetS compared with participants who were free of the MetS and diabetes. Associations were found for most of the components of the MetS with <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that in adults without known heart disease, the MetS, most of its components and diabetes are associated with a higher prevalence of calcified atherosclerotic plaque in the thoracic arteries in a multi\u2010ethnic population of men and women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.12958","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T05:59:06Z","timestamp":1444283946000},"page":"912-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The metabolic syndrome and diabetes mellitus as predictors of thoracic aortic calcification as detected by non\u2010contrast computed tomography in the Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1111","volume":"33","author":[{"given":"R.","family":"Katz","sequence":"first","affiliation":[{"name":"Department of Statistics University of Washington Seattle WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Budoff","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor\u2010UCLA Torrance CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. D.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Washington Seattle WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. D.","family":"Wong","sequence":"additional","affiliation":[{"name":"Heart Disease Prevention Program University of California, Irvine, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nasir","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Boston Boston, MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90530-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000091393.32060.0E"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90505-U"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(03)80081-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq1201.100257"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00193-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.598086"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"S5","article-title":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","volume":"26","year":"2003","journal-title":"Diabetes Care"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2341040439"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-T"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.208.3.9722864"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000080897.52664.94"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.032"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.1.106"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.22.2644"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.11.2676"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000111245.75752.C6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0816"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.11.019"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.11.005"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.05.004"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.11.017"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.09.041"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.02.004"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.09.013"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.138396"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.712141"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2010.11.002"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.12958","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.12958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:23:22Z","timestamp":1696307002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.12958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,8]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/dme.12958"],"URL":"https:\/\/doi.org\/10.1111\/dme.12958","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,8]]},"assertion":[{"value":"2015-09-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}