{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T17:07:58Z","timestamp":1778432878053,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T00:00:00Z","timestamp":1449360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Diabetic kidney disease independently predicts cardiovascular disease and premature death. We examined the burden of chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>, defined as an estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> &lt; 60 ml\/min\/1.73 m<jats:sup>2<\/jats:sup>) and quality of care in a cross\u2010sectional survey of adults (age \u2265 18 years) with Type 2 diabetes across Asia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Joint Asia Diabetes Evaluation programme is a disease\u2010management programme implemented using an electronic portal that systematically captures clinical characteristics of all patients enrolled. Between July 2007 and December 2012, data on 28 110 consecutively enrolled patients (China: 3415, Hong Kong: 15 196, India: 3714, Korea: 1651, Philippines: 3364, Vietnam: 692, Taiwan: 78) were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this survey, 15.9% of patients had <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>, 25.0% had microalbuminuria and 12.5% had macroalbuminuria. Patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> were less likely to achieve HbA<jats:sub>1c<\/jats:sub> &lt; 53 mmol\/mol (7.0%) (36.0% vs. 42.3%) and blood pressure &lt; 130\/80 mmHg (20.8% vs. 35.3%), and were more likely to have retinopathy (26.2% vs. 8.7%), sensory neuropathy (29.0% vs. 7.7%), cardiovascular disease (26.6% vs. 8.7%) and self\u2010reported hypoglycaemia (18.9% vs. 8.2%). Despite high frequencies of albuminuria (74.8%) and dyslipidaemia (93.0%) among <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> patients, only 49.0% were using renin\u2013angiotensin system inhibitors and 53.6% were on statins. On logistic regression, old age, male gender, tobacco use, long disease duration, high HbA<jats:sub>1c<\/jats:sub>, blood pressure and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, and low <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> cholesterol were independently associated with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> (all <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The poor control of risk factors, suboptimal use of organ\u2010protective drugs and high frequencies of hypoglycaemia highlight major treatment gaps in patients with diabetic kidney disease in Asia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13014","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T09:02:41Z","timestamp":1446109361000},"page":"1230-1239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Quality of care in patients with diabetic kidney disease in Asia: The Joint Asia Diabetes Evaluation (<scp>JADE<\/scp>) Registry"],"prefix":"10.1111","volume":"33","author":[{"given":"A. O.","family":"Luk","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Li","sequence":"additional","affiliation":[{"name":"Asia Diabetes Foundation Prince of Wales Hospital Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Asia Diabetes Foundation Prince of Wales Hospital Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Li","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Weng","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangdong Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology China\u2013Japan Friendship Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. B.","family":"Chan","sequence":"additional","affiliation":[{"name":"Qualigenics Diabetes Centre Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. C.","family":"Tsang","sequence":"additional","affiliation":[{"name":"Alice Ho Nethersole Hospital Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Dr M.K. Mukhopadhyay's Diabetic Clinic Kolkata"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Ojha","sequence":"additional","affiliation":[{"name":"ILS Hospital Salt Lake India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. G.","family":"Hong","sequence":"additional","affiliation":[{"name":"Hallym University College of Medicine Gangwon\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"Yoon","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea Seocho\u2010gu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Sobrepena","sequence":"additional","affiliation":[{"name":"Heart of Jesus Hospital San Jose City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Toledo","sequence":"additional","affiliation":[{"name":"Senor Sto. Nino Hospital Tarlac Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Duran","sequence":"additional","affiliation":[{"name":"New Bilibid Prison Hospital Bureau of Corrections Muntinlupa Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Sheu","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Q. Do","sequence":"additional","affiliation":[{"name":"Bach Mai Hospital Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. K.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"HCMC University of Pharmaceutical and Medicine Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P.","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. C.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Prince of Wales Hospital Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"Tong","sequence":"additional","affiliation":[{"name":"Qualigenics Diabetes Centre Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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