{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:09:16Z","timestamp":1759410556898,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["C2250068"],"award-info":[{"award-number":["C2250068"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To elucidate varicella zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>)\u2010specific cell\u2010mediated immunity and humoral immunogenicity against live attenuated Oka varicella zoster vaccine concurrently vaccinated with 23\u2010valent pneumococcal polysaccharide vaccine (<jats:styled-content style=\"fixed-case\">PPSV<\/jats:styled-content>23) in elderly people with diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010blind randomized controlled single\u2010centre study of 60\u201370\u2010year\u2010old people with diabetes compared immunity and safety profiles 3 months after one dose of varicella zoster vaccine or placebo. <jats:styled-content style=\"fixed-case\">PPSV<\/jats:styled-content>23 was immunized simultaneously. Primary analysis evaluated cell\u2010mediated immunity using the <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> skin test. Secondary analyses were a <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> interferon\u2013\u03b3 enzyme\u2010linked immunospot (<jats:styled-content style=\"fixed-case\">ELISPOT<\/jats:styled-content>) assay and immunoadherence haemagglutination test. Adverse experiences were recorded using diary questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By intent\u2010to\u2010treat analysis, 27 participants with diabetes who had been administered the vaccine were compared with 27 participants who were given a placebo. Changes in skin test scores were 0.41 \u00b1 0.80 and 0.11 \u00b1 0.93 (<jats:italic>P<\/jats:italic> = 0.2155), and geometric mean fold rises of the <jats:styled-content style=\"fixed-case\">ELISPOT<\/jats:styled-content> counts were 1.2 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.2, 7.9] and 1.2 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.2, 7.3) (<jats:italic>P<\/jats:italic> = 0.989) in the vaccine and placebo groups, respectively. The geometric mean titre did not increase 3 months after vaccination in either group. No vaccination\u2010related severe adverse experience was reported and no participant developed herpes zoster.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our previous results demonstrated that varicella zoster vaccine safely enhanced <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>\u2010specific immunity in elderly people with or without diabetes. The results of this study showed that varicella zoster vaccine can be used safely, but it cannot boost virus\u2010specific immunity in elderly people with diabetes when administered with concurrent <jats:styled-content style=\"fixed-case\">PPSV<\/jats:styled-content>23. Alternative strategies are needed to prevent <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>\u2010associated diseases in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13038","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T21:39:20Z","timestamp":1448487560000},"page":"1094-1101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and safety of live varicella zoster vaccine in diabetes: a randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-0797","authenticated-orcid":false,"given":"A.","family":"Hata","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Center for Diabetes and Endocrinology Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka 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