{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:24:46Z","timestamp":1764689086931},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Few studies have analysed the presence of hearing abnormalities in diabetes. We assessed the presence of subclinical auditory alterations and their possible association with early vascular and neurological dysfunction in young adults with Type 1 diabetes of long duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one patients with Type 1 diabetes (mean age 33 \u00b1 2.3 years, disease duration 25.7 \u00b1 4.2 years) and 10 healthy controls underwent pure tone audiometry (<jats:styled-content style=\"fixed-case\">PTA<\/jats:styled-content>), distortion product otoacoustic emission (<jats:styled-content style=\"fixed-case\">DPOAE<\/jats:styled-content>) and auditory brainstem response (<jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content>) analyses. Associations with metabolic variables and chronic complications were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy controls, patients with diabetes had significantly higher mean hearing thresholds, although still within the normoacusic range. <jats:styled-content style=\"fixed-case\">DPOAE<\/jats:styled-content> intensities at medium frequencies (2.8\u20134 <jats:styled-content style=\"fixed-case\">kH<\/jats:styled-content>z) were significantly lower in patients with diabetes. In <jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content>, in addition to waves I, <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and V, we observed the appearance of a visible wave <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> in patients with diabetes compared with controls (prevalence 61% vs. 10%, <jats:italic>P<\/jats:italic> &lt; 0.05), and its appearance was related to a prolonged I\u2013V interval (4.40 \u00b1 0.62 ms vs. 4.19 \u00b1 0.58 ms, <jats:italic>P<\/jats:italic> &lt; 0.05). Diastolic blood pressure was higher in people with abnormal <jats:styled-content style=\"fixed-case\">DPOAE<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.05), whereas systolic blood pressure correlated with wave V and interpeak I\u2013V interval latencies. A trend towards an association between evidence of wave <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and the presence of somatic neuropathy or abnormal cardiovascular autonomic tests was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Young adults with long\u2010term Type 1 diabetes have subclinical abnormalities in qualitative auditory perception, despite normal hearing thresholds, which might reflect neuropathic and\/or vascular alterations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13039","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T21:28:41Z","timestamp":1448486921000},"page":"1260-1267","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cochlear, auditory brainstem responses in Type 1 diabetes: relationship with metabolic variables and diabetic complications"],"prefix":"10.1111","volume":"33","author":[{"given":"A.","family":"Lasagni","sequence":"first","affiliation":[{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lacilla","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Raviolo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Trento","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Camussi","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Grassi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Charrier","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Albera","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Porta","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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