{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:22:04Z","timestamp":1788740524804,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T00:00:00Z","timestamp":1452384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH Clinical and Translational Science Award","award":["UL1 RR025744"],"award-info":[{"award-number":["UL1 RR025744"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>There is general acceptance that the physiological relationship between insulin sensitivity and insulin secretion is hyperbolic. This conclusion has evolved from studies in which one test assessed both variables, and changes in plasma insulin concentration were used as a surrogate measure for insulin secretion rate. The aim of this study was to see if a hyperbolic relationship would also emerge when separate and direct measures were used to quantify both insulin sensitivity and insulin secretion rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Steady\u2010state plasma glucose (<jats:styled-content style=\"fixed-case\">SSPG<\/jats:styled-content>) was determined in 146 individuals without diabetes using the insulin suppression test, with 1\/<jats:styled-content style=\"fixed-case\">SSPG<\/jats:styled-content> used to quantify insulin sensitivity. The graded\u2010glucose infusion test was used to quantify insulin secretion rate. Plasma glucose and insulin concentrations obtained during an oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) were used to calculate surrogate estimates of insulin action and insulin secretion rate. A hyperbolic relationship was assumed if the \u03b2 coefficient was near \u22121 using the following model: log (insulin secretion measure) = constant + \u03b2 \u00d7 log (insulin sensitivity measure).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> calculations of insulin sensitivity (Matsuda) and plasma insulin response [ratio of insulin\/glucose area\u2010under\u2010the\u2010curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) or insulin total <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>] provided the expected hyperbolic relationship [\u03b2 = \u22120.95, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (\u22121.09, \u22120.82); \u22121.06 (\u22121.14, \u22120.98)]. Direct measurements of insulin sensitivity and insulin secretion rate did not yield the same curvilinear relationship [\u03b2 = \u22121.97 (\u22123.19, \u22121.36)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings demonstrate that the physiological relationship between insulin sensitivity and insulin secretion rate is not necessarily hyperbolic, but will vary with the method(s) by which it is determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13055","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T07:13:16Z","timestamp":1450249996000},"page":"961-967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relationship between insulin sensitivity and insulin secretion rate: not necessarily hyperbolic"],"prefix":"10.1111","volume":"33","author":[{"given":"S. H.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medicine Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Silvers","sequence":"additional","affiliation":[{"name":"San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Viren","sequence":"additional","affiliation":[{"name":"San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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