{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:39:00Z","timestamp":1761896340291,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the usage and real\u2010life effectiveness of intensification therapies in people with Type 2 diabetes treated with basal insulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used population\u2010based healthcare databases in Denmark during 2000\u20132012 to identify all individuals with a first basal insulin prescription (with or without oral drugs), and evaluated subsequent intensification therapy with bolus insulin, premixed insulin or glucagon\u2010like peptide\u20101 (<jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101) receptor agonists. Poisson regression was used to compute the adjusted relative risks of reaching glycaemic control targets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 7034 initiators of basal insulin (median age 64 years, diabetes duration 5.3 years, 84% with oral co\u2010medication and median (interquartile range) pre\u2010insulin HbA<jats:sub>1c<\/jats:sub> level 77 (65\u201392) mmol\/mol [9.2% (8.1\u201310.6%)]. Of these, 3076 (43.7%) received intensification therapy after a median of 11 months: 58.5% with premixed insulin, 29.0% with bolus insulin, 10.6% with <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 receptor agonists, and 1.9% with more than one add\u2010on. Overall, 22% had attained an HbA<jats:sub>1c<\/jats:sub> level of &lt; 53 mmol\/mol (&lt; 7%) by 3\u20136 months after intensification, while 38% attained an HbA<jats:sub>1c<\/jats:sub> &lt; 58 mmol\/mol (&lt; 7.5%). Compared with premixed insulin intensification, attainment of HbA<jats:sub>1c<\/jats:sub> &lt; 53 and &lt; 58 mmol\/mol was similar with bolus insulin add\u2010on [adjusted relative risk 1.03 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.86\u20131.24) and 1.02 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.91\u20131.15), and higher for <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 receptor agonist add\u2010on [adjusted relative risk 1.56 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.27\u20131.92) and 1.27 (1.10\u20131.47)]<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among people with Type 2 diabetes, 22 and 38% reached a target HbA<jats:sub>1c<\/jats:sub> &lt; 53 mmol\/mol (&lt; 7%) or &lt; 58 mmol\/mol (&lt; 7.5%), respectively, after intensification of their basal insulin therapy. Compared with premixed insulin, target attainment was similar with bolus insulin and higher with <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20101 receptor agonists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13168","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T15:59:53Z","timestamp":1465487993000},"page":"213-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of intensification therapies in Danes with Type 2 diabetes who use basal insulin: a population\u2010based study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-3474","authenticated-orcid":false,"given":"R. W.","family":"Thomsen","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Baggesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"S\u00f8gaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"N\u00f8rrelund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Buhl","sequence":"additional","affiliation":[{"name":"Novo Nordisk Scandinavia AB \u00d8restad Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Haase","sequence":"additional","affiliation":[{"name":"Novo Nordisk Scandinavia AB \u00d8restad Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0413"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1710"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905479"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1122"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-1365"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03694.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0331"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5951"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1595-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2718"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-2-201101180-00300"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4236\/jdm.2014.42022"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2010.0221"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S30082"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12484"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S13458"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2983"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S17901"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0902"},{"issue":"1","key":"e_1_2_8_23_1","first-page":"S4","article-title":"Standards of medical care in diabetes\u20102015: summary of revisions","volume":"38","author":"American Diabetes Association","year":"2015","journal-title":"Diabetes Care"},{"key":"e_1_2_8_24_1","unstructured":"The Danish College of General Practitioners (DSAM) and the Danish Endocrine Society (DES). Guidelines for type 2\u2010diabetes 2014 revision. Farmakologisk behandling af type 2\u2010diabetes. [in Danish]. Available athttp:\/\/www.dsam.dk\/flx\/publikationer\/. 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