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Med."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the association of cutaneous nevi with Type 2 diabetes risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectivly examined the associations between nevus count and risk of Type 2 diabetes among 26 240 men (1988\u20132010) from the Health Professionals Follow\u2010up Study and 67 050 women (1986\u20132010) from the Nurses' Health Study. Information on the numbers of cutaneous nevi on arms at baseline and incident cases of Type 2 diabetes was collected using validated questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 1 879 287 person\u2010years of follow\u2010up, we documented 9040 incident cases of Type 2 diabetes. After adjustment for age, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and other diabetes risk factors, greater number of nevi was associated with higher risk of Type 2 diabetes. Multivariable\u2010adjusted hazard ratios for &lt;1, 1\u20135, 6\u201314 and \u226515 nevi were 1.00 (reference), 1.02 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.93, 1.13), 1.08 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.88, 1.34) and 1.57 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.15, 2.15), respectively, for men (<jats:italic>P<\/jats:italic> for linear trend = 0.01), and 1.00 (reference), 1.07 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.02, 1.13), 0.98 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.87, 1.10), and 1.25 (1.01, 1.54), respectively, for women (<jats:italic>P<\/jats:italic> for linear trend = 0.05). This positive association remained consistent across subgroups stratified by age, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, multivitamin use, smoking status, alcohol, physical activity, history of hypercholesterolaemia, family history of diabetes, history of hypertension and menopausal status (in women).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cutaneous nevus count may represent a novel marker for development of Type 2 diabetes, suggesting a possible unique melanocytic nevus\u2010related mechanism in the pathogenesis of Type 2 diabetes. Further studies are warranted to confirm the findings and to investigate the underlying mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13297","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T06:24:52Z","timestamp":1480919092000},"page":"925-933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations between benign cutaneous nevi and risk of Type 2 diabetes mellitus in men and women: results from two prospective cohort studies"],"prefix":"10.1111","volume":"34","author":[{"given":"H.","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy of Tianjin Tianjin Medical University Cancer Institute and Hospital Tianjin China"},{"name":"Department of Epidemiology Richard M. Fairbanks School of Public Health Indiana University Indianapolis IN"},{"name":"Melvin and Bren Simon Cancer Center Indiana University Indianapolis IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Richard M. Fairbanks School of Public Health Indiana University Indianapolis IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.\u2010Q.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Warren Alpert Medical School, Brown University Providence RI"},{"name":"Department of Epidemiology School of Public Health Brown University Providence RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Manson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA"},{"name":"Division of Preventive Medicine Department of Medicine, Brigham and Women's Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. B.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. 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