{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:52:04Z","timestamp":1783468324072,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009860","name":"Ramaciotti Foundations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008713","name":"Diabetes Australia Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the relationships of diabetes and albuminuria with all\u2010cause mortality and cardiovascular disease outcomes in a population without prior cardiovascular disease using data from the Darwin Region Urban Indigenous Diabetes (DRUID) study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective cohort study of 706 participants (aged 15\u201381 years, 68% women) without prior cardiovascular disease who underwent a 75\u2010g oral glucose tolerance test. Deaths and fatal or non\u2010fatal cardiovascular disease were determined over 7 years, and hazard ratios with 95% CIs and population attributable risks were estimated for baseline glycaemia and albuminuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with normoglycaemia and after adjustment for age, sex, hypertension, dyslipidaemia and smoking, known diabetes was associated with an adjusted hazard ratio of 4.8 (95% CI 1.5\u201314.7) for all\u2010cause mortality and 5.6 (95% CI 2.1\u201315.2) for cardiovascular disease. Compared with normoalbuminuria, the respective adjusted risks for macroalbuminuria were 10.9 (95% CI 3.7\u201332.1) and 3.9 (95% CI 1.4\u201310.8). The Adjusted all\u2010cause mortality and cardiovascular disease estimated population attributable risks for diabetes were 27% and 32%, and for albuminuria they were 32% and 21%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our study population, the burden of mortality and cardiovascular disease was largely driven by diabetes and albuminuria. This finding on the influence of diabetes and albuminuria is consistent with reports in other high\u2010risk Indigenous populations and should be better reflected in risk scores and intervention programmes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13360","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T16:56:58Z","timestamp":1491411418000},"page":"946-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Associations of mortality and cardiovascular disease risks with diabetes and albuminuria in urban Indigenous Australians: the <scp>DRUID<\/scp> follow\u2010up study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4284-1716","authenticated-orcid":false,"given":"E. L. M.","family":"Barr","sequence":"first","affiliation":[{"name":"Menzies School of Health Research Darwin Australia"},{"name":"Baker Heart and Diabetes Institute Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Darwin Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tatipata","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Darwin Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Dunbar","sequence":"additional","affiliation":[{"name":"Charles Darwin University Darwin Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kangaharan","sequence":"additional","affiliation":[{"name":"Royal Darwin Hospital Darwin Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Guthridge","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Darwin Australia"},{"name":"Health Gains Planning Northern Territory Department of Health Darwin Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Q.","family":"Li","sequence":"additional","affiliation":[{"name":"Health Gains Planning Northern Territory Department of Health Darwin Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Condon","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Darwin Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Baker Heart and Diabetes Institute Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"O'Dea","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide Australia"},{"name":"University of Melbourne Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Maple\u2010Brown","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Darwin Australia"},{"name":"Royal Darwin Hospital Darwin Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008302"},{"key":"e_1_2_9_3_1","volume-title":"Expert meeting on Indigenous Peoples Report, Diabetes and Development Report","author":"International Diabetes Federation","year":"2012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17018-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.06.012"},{"key":"e_1_2_9_6_1","unstructured":"Australian Institute of Health and Welfare (AIHW).The health and welfare of Australia's Indigenous People. 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