{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:26:49Z","timestamp":1762522009650,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate whether plasma glycated albumin, which provides an integrated measure of plasma glucose levels over the preceding 2\u20134 weeks, better reflects changes in postprandial glucose excursions than HbA<jats:sub>1c<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>People with suboptimum glycaemic control on dual oral therapy were enrolled in the Treating\u2010to\u2010Target\u2010in\u2010Type 2 diabetes (4\u2010T) trial, in which participants were randomized to the addition of once\u2010daily basal insulin, twice\u2010daily biphasic insulin or thrice\u2010daily prandial insulin. Glycated albumin levels were assayed enzymatically from baseline and 1\u2010year fasting plasma samples. We evaluated robust correlations of glycated albumin and HbA<jats:sub>1c<\/jats:sub> both with fasting and postprandial glucose levels at these two time points, and with insulin\u2010induced changes in the postprandial excursion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Requisite data were available for 625 of the participants in the 4\u2010T trial. Their mean (\u00b1<jats:sc>sd<\/jats:sc>) age was 62 \u00b1 10 years and body weight was 85.8 \u00b1 15.9 kg, and their median (interquartile range) diabetes duration was 9 (6, 13) years. Partial correlations at baseline and 1 year between postprandial glucose excursions and glycated albumin\/HbA<jats:sub>1c<\/jats:sub>, after adjusting for fasting glucose, were 0.27\/0.15 and 0.22\/0.18, respectively. Glycated albumin, compared with HbA<jats:sub>1c<\/jats:sub>, explained 66% more of the variation in postprandial glucose excursions at baseline. At 1 year, postprandial glucose excursions on basal, biphasic and prandial and insulin therapy were reduced by 0.43, 0.78 and 1.88 mmol\/l, respectively. These reductions were associated with changes in both glycated albumin and HbA<jats:sub>1c<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; 0.01), with a stronger association for glycated albumin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Changes in glycated albumin and HbA<jats:sub>1c<\/jats:sub> reflect changes in postprandial glucose excursions to a similar extent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13376","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T11:24:46Z","timestamp":1494069886000},"page":"1284-1290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Do glycoalbumin levels preferentially reflect changes in postprandial glucose excursions?"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0848-7194","authenticated-orcid":false,"given":"S. K.","family":"Paul","sequence":"first","affiliation":[{"name":"Clinical Trials and Biostatistics Unit QIMR Berghofer Medical Research Institute Brisbane Queensland"},{"name":"Melbourne EpiCentre University of Melbourne and Melbourne Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"Holman","sequence":"additional","affiliation":[{"name":"Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12143"},{"key":"e_1_2_9_3_1","first-page":"145","article-title":"Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk","volume":"6","author":"Aryangat AV","year":"2010","journal-title":"Vasc Health Risk Manag"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0634"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016109787354169"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.03.021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.115"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K07E-089"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2008.04.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2012.12.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089478"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0782"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146780"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.02.019"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.08.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-138"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.04.025"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.05.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1945"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.05.045"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.09.005"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-011-0036-9"},{"key":"e_1_2_9_24_1","first-page":"274","article-title":"Study of glycated albumin cut\u2010off point in diabetes mellitus and impaired glucose regulation","volume":"45","author":"Zhang T","year":"2014","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa075392"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905479"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905479"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cageo.2011.06.021"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.08.008"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070772"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.04.007"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70199-2"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1462"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.13376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.13376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:32:09Z","timestamp":1696293129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.13376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,13]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/dme.13376"],"URL":"https:\/\/doi.org\/10.1111\/dme.13376","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"type":"print","value":"0742-3071"},{"type":"electronic","value":"1464-5491"}],"subject":[],"published":{"date-parts":[[2017,6,13]]},"assertion":[{"value":"2017-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}