{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:59:15Z","timestamp":1777604355866,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,23]],"date-time":"2017-07-23T00:00:00Z","timestamp":1500768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare long\u2010term HbA<jats:sub>1c<\/jats:sub> changes associated with different insulin pumps during routine care in a large cohort of adults with Type 1 diabetes representative of other clinic populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Observational, retrospective study of 508 individuals starting pump therapy between 1999 and 2014 (mean age, 40 years; 55% women; diabetes duration, 20 years; 94% Type 1 diabetes; median follow\u2010up, 3.7 years). Mixed linear models compared covariate\u2010adjusted HbA<jats:sub>1c<\/jats:sub> changes associated with different pump makes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pumps compared were: 50% Medtronic, 24% Omnipod, 14% Roche and 12% Animas. Overall HbA<jats:sub>1c<\/jats:sub> levels improved and improvements were maintained during a follow\u2010up extending to 10 years (HbA<jats:sub>1c<\/jats:sub>: pre\u2010continuous subcutaneous insulin infusion (pre\u2010<jats:styled-content style=\"fixed-case\">CSII<\/jats:styled-content>) vs. 12 months post <jats:styled-content style=\"fixed-case\">CSII<\/jats:styled-content>, 71 (61, 82) vs. 66 (56, 74) mmol\/mol; 8.7 (7.7, 9.6) vs. 8.2 (7.3, 8.9)%; <jats:italic>P<\/jats:italic> &lt; 0.0001). The percentage of individuals with HbA<jats:sub>1c<\/jats:sub> \u2265 64 mmol\/mol (8.0%) reduced from a pre\u2010<jats:styled-content style=\"fixed-case\">CSII<\/jats:styled-content> level of 68% to 55%. After adjusting for baseline confounders, there were no between\u2010pump differences in HbA<jats:sub>1c<\/jats:sub> lowering (<jats:italic>P<\/jats:italic> = 0.44), including a comparison of patch pumps with traditional catheter pumps (<jats:italic>P<\/jats:italic> = 0.63). There were no significant (<jats:italic>P<\/jats:italic> &lt; 0.05) between\u2010pump differences in HbA<jats:sub>1c<\/jats:sub> lowering in pre\u2010specified subgroups stratified by pre\u2010pump HbA<jats:sub>1c<\/jats:sub>, age or diabetes duration. HbA<jats:sub>1c<\/jats:sub> lowering was positively related to baseline HbA<jats:sub>1c<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; 0.001) and diabetes duration (<jats:italic>P<\/jats:italic> = 0.017), and negatively related to the number of years of <jats:styled-content style=\"fixed-case\">CSII<\/jats:styled-content> use (<jats:italic>P<\/jats:italic> = 0.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Under routine care conditions, there were no covariate\u2010adjusted differences in HbA<jats:sub>1c<\/jats:sub> lowering when comparing different pump makes, including a comparison of patch pumps vs. traditional catheter pumps. Therefore, the choice of <jats:styled-content style=\"fixed-case\">CSII<\/jats:styled-content> make should not be influenced by the desired degree of HbA<jats:sub>1c<\/jats:sub> lowering.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13412","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T16:37:03Z","timestamp":1498063023000},"page":"1372-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Comparison of different insulin pump makes under routine care conditions in adults with Type 1 diabetes"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9602-1962","authenticated-orcid":false,"given":"L.","family":"Leelarathna","sequence":"first","affiliation":[{"name":"Manchester Diabetes Centre Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Centre for Biostatistics, Manchester Academic Health Science Centre University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hindle","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Markakis","sequence":"additional","affiliation":[{"name":"Manchester Diabetes Centre Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Alam","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Manchester Diabetes Centre Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Morris","sequence":"additional","affiliation":[{"name":"Manchester Diabetes Centre Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Urwin","sequence":"additional","affiliation":[{"name":"Manchester Diabetes Centre Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Jinadev","sequence":"additional","affiliation":[{"name":"Manchester Diabetes Centre Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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