{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:06:54Z","timestamp":1781251614965,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the incidence of hyperglycaemia among participants with low, elevated and normal serum thyroid\u2010stimulating hormone concentration, as well as the incidence of abnormal thyroid function test results among participants with normal blood glucose and those with hyperglycaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective study, a cohort of 72 003 participants with normal, low and elevated serum thyroid\u2010stimulating hormone concentration were followed from the study beginning to the first report of diabetes and prediabetes. A proportional hazards regression model was used to calculate the hazard ratios and 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s for each outcome, adjusting for age, sex, education level, smoking, alcohol consumption and obesity. Analyses for the association between dysglycaemia and incident abnormal thyroid function test were also conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median 2.6 year follow\u2010up, the incident rates for dysglycaemia, particularly prediabetes, were substantially higher in participants with elevated thyroid\u2010stimulating hormone concentrations at baseline, while the rates for participants with normal and low thyroid\u2010stimulating hormone were similar. After controlling for risk factors, participants with elevated thyroid\u2010stimulating hormone retained a 15% increase in risk of prediabetes (adjusted hazard ratio 1.15, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.04\u20131.26), but were not at greater risk of diabetes (adjusted hazard ratio 0.96, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.64\u20131.44). By contrast, participants with normal and low thyroid\u2010stimulating hormone concentrations had similar dysglycaemia risks. Participants with diabetes and prediabetes were not at greater risks of developing abnormal thyroid function test results when compared with participants with euglycaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>People with elevated serum thyroid\u2010stimulating hormone concentration are at greater risk of developing prediabetes. Whether this includes a greater risk of developing frank diabetes may require an extended period of follow\u2010up to clarify.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13420","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T01:52:44Z","timestamp":1500083564000},"page":"1584-1590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association between thyroid dysfunction and dysglycaemia: a prospective cohort study"],"prefix":"10.1111","volume":"34","author":[{"given":"C.\u2010H.","family":"Chang","sequence":"first","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine College of Public Health, National Taiwan University Taipei"},{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei"},{"name":"Department of Medicine College of Medicine, National Taiwan University Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2968-1068","authenticated-orcid":false,"given":"Y.\u2010C.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine College of Public Health, National Taiwan University Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010R.","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei"},{"name":"Department of Medicine College of Medicine, National Taiwan University Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010W.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei"},{"name":"Department of Medicine College of Medicine, National Taiwan University Taipei"},{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin Branch Dou\u2010Liou City Yun\u2010Lin County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.\u2010M.","family":"Chuang","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine College of Public Health, National Taiwan University Taipei"},{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei"},{"name":"Department of Medicine College of Medicine, National Taiwan University Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Caffrey","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular and Metabolic Disease University of North Texas Health Science Center Fort Worth TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010K.","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine College of Public Health, National Taiwan University Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.228"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr030"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2010.02376.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04029.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.11.1573"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4158\/1934-2403-8.6.457"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.11.1573"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60952-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/152850"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.899"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0108"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0797"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/390534"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/439463"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.121"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0543"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0249"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0223"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002193"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.13420","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.13420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:34:55Z","timestamp":1696275295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.13420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/dme.13420"],"URL":"https:\/\/doi.org\/10.1111\/dme.13420","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]},"assertion":[{"value":"2017-07-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}