{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:46:23Z","timestamp":1791110783043,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["HTA 09\/75\/01"],"award-info":[{"award-number":["HTA 09\/75\/01"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine clinical outcomes and explore prognostic factors related to ulcer healing in people with a clinically infected diabetic foot ulcer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicentre, prospective, observational study reviewed participants\u2019 data at 12 months after culture of a diabetic foot ulcer requiring antibiotic therapy. From participants\u2019 notes, we obtained information on the incidence of wound healing, ulcer recurrence, lower extremity amputation, lower extremity revascularization and death. We estimated the cumulative incidence of healing at 6 and 12 months, adjusted for lower extremity amputation and death using a competing risk analysis, and explored the relationship between baseline factors and healing incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first year after culture of the index ulcer, 45\/299 participants (15.1%) had died. The ulcer had healed in 136 participants (45.5%), but recurred in 13 (9.6%). An ipsilateral lower extremity amputation was recorded in 52 (17.4%) and revascularization surgery in 18 participants (6.0%). Participants with an ulcer present for ~2 months or more had a lower incidence of healing (hazard ratio 0.55, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.39 to 0.77), as did those with a <jats:styled-content style=\"fixed-case\">PEDIS<\/jats:styled-content> (perfusion, extent, depth, infection, sensation) perfusion grade of \u22652 (hazard ratio 0.37, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.25 to 0.55). Participants with a single ulcer on their index foot had a higher incidence of healing than those with multiple ulcers (hazard ratio 1.90, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.18 to 3.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical outcomes at 12 months for people with an infected diabetic foot ulcer are generally poor. Our data confirm the adverse prognostic effect of limb ischaemia, longer ulcer duration and the presence of multiple ulcers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13537","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T15:06:42Z","timestamp":1509376002000},"page":"78-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":239,"title":["Prognosis of the infected diabetic foot ulcer: a 12\u2010month prospective observational study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-3173","authenticated-orcid":false,"given":"M.","family":"Ndosi","sequence":"first","affiliation":[{"name":"Department of Nursing and Midwifery University of the West of England Bristol UK"},{"name":"Academic Rheumatology Unit University Hospitals Bristol NHS Foundation Trust Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wright\u2010Hughes","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Backhouse","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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