{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:00:21Z","timestamp":1774461621055,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T00:00:00Z","timestamp":1520121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hong Kong College of Family Physicians research fellowship 2012"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to determine the prospective association between baseline triglyceridaemic\u2013waist phenotypes and diabetic mellitus incidence in individuals with impaired fasting glucose seen in primary care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 1101 participants (84.4% of the recruited individuals) with impaired fasting glucose were recruited from three primary care clinics during regular follow\u2010ups to monitor their chronic conditions. Baseline triglyceridaemic\u2013waist phenotypes were divided into four groups: (1) normal waistline and triglyceride level (<jats:italic>n<\/jats:italic> = 252); (2) isolated central obesity (<jats:italic>n<\/jats:italic> = 518); (3) isolated high triglyceride level (<jats:italic>n<\/jats:italic> = 80); and (4) central obesity with high triglyceride level (i.e. hypertriglyceridaemic\u2013waist phenotype) (<jats:italic>n<\/jats:italic> = 251). The presence of diabetes at follow\u2010up was determined by fasting plasma glucose (\u2265 7.0 mmol\/l) and\/or 2\u2010h 75\u2010g oral glucose tolerance test (\u2265 11.1 mmol\/l) and\/or HbA<jats:sub>1c<\/jats:sub> (47.5 mmol\/mol; \u2265 6.5%) according to American Diabetes Association diagnostic criteria. Multivariable Cox proportional hazards regressions were established to assess the impact of different triglyceridaemic\u2013waist phenotypes on time to diabetes onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a mean follow\u2010up period of 6.5 months (<jats:sc>sd<\/jats:sc> 4.7 months), the number of diabetes cases was significantly higher in the group with hypertriglyceridaemic\u2013waist phenotype (52.2%) compared with the other three phenotype groups (group 1: 28.2%; group 2: 34.6%; group 3: 30.0%). Only the hypertriglyceridaemic\u2013waist phenotype showed an increased risk of developing diabetes (hazard ratio 1.581, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.172\u20132.134; <jats:italic>P<\/jats:italic> = 0.003) compared with the group with normal waistline and triglyceride level after controlling for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of central obesity and hypertriglyceridaemia is associated with &gt; 50% risk of progression to diabetes within 6 months among individuals with impaired fasting glucose seen in primary care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13601","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T19:16:53Z","timestamp":1518549413000},"page":"576-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hypertriglyceridaemic\u2013waist phenotype and risk of diabetes in people with impaired fasting glucose in primary care: a cohort study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9399-1808","authenticated-orcid":false,"given":"V. Y.\u2010W.","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Family Medicine and Primary Care The University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Y.\u2010T.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Primary Care The University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6895-6071","authenticated-orcid":false,"given":"C. K.\u2010H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Primary Care The University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.\u2010S.","family":"Sit","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.\u2010L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Health Care Hong Kong West Cluster Hospital Authority Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.\u2010K.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Primary Care The University of Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.03.024"},{"key":"e_1_2_9_3_1","unstructured":"Task Force on Conceptual Model and Preventive Protocols.Working Group on Primary Care and Food and Health Bureau Hong Kong Reference Framework for Diabetes Care for Adults in Primary Care Settings. 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