{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:03:43Z","timestamp":1773666223111,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009418","name":"Nordsj\u00e6llands Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine whether people with Type 2 diabetes with concurrent obstructive sleep apnoea have increased arterial stiffness as compared with people with Type 2 diabetes without obstructive sleep apnoea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a study with a case\u2013control design, 40 people with Type 2 diabetes and treatment\u2010na\u00efve moderate to severe obstructive sleep apnoea (Apnoea\u2010Hypopnoea Index \u226515) and a control group of 31 people with Type 2 diabetes without obstructive sleep apnoea (Apnoea\u2010Hypopnoea Index &lt;5) were examined. Obstructive sleep apnoea status was evaluated using the ApneaLink<jats:sup>\u00ae<\/jats:sup>+ home\u2010monitoring device (Resmed Inc., San Diego, <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> USA<\/jats:styled-content>), providing the Apnoea\u2010Hypopnoea Index scores. Arterial stiffness was assessed according to carotid\u2010femoral pulse wave velocity using the Sphygmocor device and the oscillometric Mobil\u2010O\u2010Graph<jats:sup>\u00ae<\/jats:sup> (I.E.M. GmbH, Stolberg, Germany).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Carotid\u2010femoral pulse wave velocity was not significantly different between participants with Type 2 diabetes with obstructive sleep apnoea and those without obstructive sleep apnoea (10.7\u00b12.2 m\/s vs 10.3\u00b12.1 m\/s; <jats:italic>P<\/jats:italic>=0.513), whereas oscillometric pulse wave velocity was significantly higher in participants with Type 2 diabetes with obstructive sleep apnoea than in those without obstructive sleep apnoea (9.5\u00b11.0 m\/s vs 8.6\u00b11.4 m\/s; <jats:italic>P<\/jats:italic>=0.002). In multiple regression analysis, age (<jats:italic>P<\/jats:italic>=0.002), gender (men; <jats:italic>P<\/jats:italic>=0.018) and HbA<jats:sub>1c<\/jats:sub> (<jats:italic>P<\/jats:italic>=0.027) were associated with carotid\u2010femoral pulse wave velocity, and systolic blood pressure (<jats:italic>P<\/jats:italic>=0.004) and age (<jats:italic>P<\/jats:italic>&lt;0.001) were associated with oscillometric pulse wave velocity. After adjustment, presence of obstructive sleep apnoea was not independently associated with pulse wave velocity whether assessed by tonometry or oscillometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the present study did not find an age\u2010 and blood pressure\u2010independent association between moderate to severe obstructive sleep apnoea and arterial stiffness in non\u2010sleepy people with Type 2 diabetes. (Clinical trial registration number: NCT02482584)<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13666","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T21:29:48Z","timestamp":1526419788000},"page":"1391-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Arterial stiffness in people with Type 2 diabetes and obstructive sleep apnoea"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4285-6766","authenticated-orcid":false,"given":"M.","family":"Hvelplund Kristiansen","sequence":"first","affiliation":[{"name":"Nordsjaellands University Hospital Hilleroed Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Bangh\u00f8j","sequence":"additional","affiliation":[{"name":"Nordsjaellands University Hospital Hilleroed Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Laugesen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Tarnow","sequence":"additional","affiliation":[{"name":"Nordsjaellands University Hospital Hilleroed Denmark"},{"name":"Steno Diabetes Centre Sjaelland Holbaek Sygehus Holbaek Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.720847"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.2.2.120"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0918-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1689-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000033"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl254"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.886655"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.063"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12477"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27497"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja13.10579"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.964783"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2012.03.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-500OC"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-010-0465-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.26861"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834fa8b0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200008000-00007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.27"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.176313"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e3283614168"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229680800200421"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.137653"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.8.1081"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000371768"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000154229.97341.d2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq165"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32832cb04e"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000379481.07457.c3"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.13666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.13666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T08:43:27Z","timestamp":1695026607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.13666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,24]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/dme.13666"],"URL":"https:\/\/doi.org\/10.1111\/dme.13666","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,24]]},"assertion":[{"value":"2018-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}