{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:31:40Z","timestamp":1784068300088,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007\u20102013"],"award-info":[{"award-number":["FP7\/2007\u20102013"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare clinical baseline data in individuals with Type 2 diabetes and normoalbuminuria, who are at high or low risk of diabetic kidney disease based on the urinary proteomics classifier <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>273.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective, randomized, double\u2010blind, placebo\u2010controlled international multicentre clinical trial and observational study in participants with Type 2 diabetes and normoalbuminuria, stratified into high\u2010 or low\u2010risk groups based on <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>273 score. Clinical baseline data for the whole cohort and stratified by risk groups are reported. The associations between <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>273 and traditional risk factors for diabetic kidney disease were evaluated using univariate and logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1777 participants from 15 centres were included, with 12.3% of these having a high\u2010risk proteomic pattern. Participants in the high\u2010risk group (<jats:italic>n<\/jats:italic>=218), were more likely to be men, were older, had longer diabetes duration, a lower estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> and a higher urinary albumin:creatinine ratio than those in the low\u2010risk group (<jats:italic>n<\/jats:italic>=1559, <jats:italic>P<\/jats:italic>&lt;0.02). Numerical differences were small and univariate regression analyses showed weak associations (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> &lt; 0.04) of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>273 with each baseline variable. In a logistic regression model including clinical variables known to be associated with diabetic kidney disease, estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>, gender, log urinary albumin:creatinine ratio and use of renin\u2010angiotensin system\u2010blocking agents remained significant determinants of the <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>273 high\u2010risk group: area under the curve 0.72 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.68\u20130.75; <jats:italic>P<\/jats:italic>&lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this population of individuals with Type 2 diabetes and normoalbuminuria, traditional diabetic kidney disease risk factors differed slightly between participants at high risk and those at low risk of diabetic kidney disease, based on <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>273. These data suggest that <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>273 may provide additional prognostic information over and above the variables routinely available in the clinic. Testing the added value will be subject to our ongoing study. (European Union Clinical Trials Register: Eudra<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> 2012\u2010000452\u201034 and Clinicaltrials.gov: <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02040441).<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13669","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T11:46:28Z","timestamp":1526903188000},"page":"1375-1382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Characteristics of high\u2010 and low\u2010risk individuals in the <scp>PRIORITY<\/scp> study: urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes"],"prefix":"10.1111","volume":"35","author":[{"given":"N.","family":"Tofte","sequence":"first","affiliation":[{"name":"Steno Diabetes Centre Copenhagen Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lindhardt","sequence":"additional","affiliation":[{"name":"Steno Diabetes Centre Copenhagen Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Adamova","sequence":"additional","affiliation":[{"name":"University Clinic of Endocrinology, Diabetes and Metabolic Disorders Skopje Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Beige","sequence":"additional","affiliation":[{"name":"Klinikum St. Georg, Nephrology and KfH Renal Unit Leipzig, Martin\u2010Luther University Halle Wittenberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W. J.","family":"Beulens","sequence":"additional","affiliation":[{"name":"Amsterdam Public Health Research Institute VU University Medical Centre Amsterdam The Netherlands"},{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Birkenfeld","sequence":"additional","affiliation":[{"name":"Clinical Study Centre Metabolic Vascular Medicine GWT TU\u2010Dresden GmbH Dresden Germany"},{"name":"Paul Langerhans Institute Dresden of the Helmholtz Centre Munich at University Hospital, and Faculty of Medicine TU Dresden Dresden Germany"},{"name":"German Centre for Diabetes Research (DZD e.V.) Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Currie","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Delles","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Dimos","sequence":"additional","affiliation":[{"name":"Diabetespraxis Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Francov\u00e1","sequence":"additional","affiliation":[{"name":"1st Department, Charles University Third Faculty of Medicine Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Frimodt\u2010M\u00f8ller","sequence":"additional","affiliation":[{"name":"Steno Diabetes Centre Copenhagen Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Girman","sequence":"additional","affiliation":[{"name":"Diabetes Centre Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"G\u00f6ke","sequence":"additional","affiliation":[{"name":"Diabetologische Schwerpunktpraxis Diabetologen Hessen Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Havrdova","sequence":"additional","affiliation":[{"name":"Diabetes Centre Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kooy","sequence":"additional","affiliation":[{"name":"Bethesda Diabetes Research Centre Hoogeveen and University Medical Centre Groningen  Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mischak","sequence":"additional","affiliation":[{"name":"Mosaiques Diagnostics Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Navis","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine University Medical Centre Groningen Groningen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Nijpels","sequence":"additional","affiliation":[{"name":"Department General Practice and Elderly Care Amsterdam Public Health VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Noutsou","sequence":"additional","affiliation":[{"name":"Diabetes Centre and 2nd Department of Internal Medicine National and Kapodistrian University of Athens Hippokratio General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Instituto de Investigacion Sanitaria de la Fundacion Jim\u00e9nez D\u00edaz UAM Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Parvanova","sequence":"additional","affiliation":[{"name":"Istituto di Richerche Farmacologiche Mario Negri Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Persson","sequence":"additional","affiliation":[{"name":"Steno Diabetes Centre Copenhagen Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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