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Med."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate depolarization and repolarization durations in people with Type 1 diabetes, including the relationship to age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>855 persons with Type 1 diabetes without known heart disease were included and matched with 1710 participants from a general population study. Clinical examinations, questionnaires and biochemistry were assessed. A 10\u2010second 12\u2010lead <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> was performed and analysed digitally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content><jats:sub>c<\/jats:sub> was longer in people with Type 1 diabetes compared to controls (414\u00b116 vs. 411\u00b119 ms, <jats:italic>P<\/jats:italic> &lt;0.001), and particularly so in young people with Type 1 diabetes. The fully adjusted increase was 13.8 ms (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 8.6\u201319.0 ms, <jats:italic>P<\/jats:italic> &lt;0.001) at age 20 years and 3.4 ms (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.5\u20135.3 ms, <jats:italic>P<\/jats:italic>&lt;0.001) at age 40 years. The rate\u2010corrected <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content><jats:sub>c<\/jats:sub> was increased in people with Type 1 diabetes (97\u00b111 vs. 95\u00b111 ms, <jats:italic>P<\/jats:italic> &lt;0.001) and was age\u2010independent (<jats:italic>P<\/jats:italic> =0.5). <jats:styled-content style=\"fixed-case\">JT<\/jats:styled-content><jats:sub>c<\/jats:sub> was increased in the young people with Type 1 diabetes (10.7 ms (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 5.4\u201316.0 ms, <jats:italic>P<\/jats:italic> &lt;0.001) at age 20 years), but not in older people with Type 1 diabetes (interaction age\u2010diabetes, <jats:italic>P<\/jats:italic> &lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For people with Type 1 diabetes, cardiac depolarization is increased at all ages, whereas repolarization is increased only relatively in young people with Type 1 diabetes. Hence, young people with Type 1 diabetes may be more prone to ventricular arrhythmias. The findings contribute to the understanding of sudden cardiac death in young people with Type 1 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13689","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T06:50:44Z","timestamp":1527144644000},"page":"1337-1344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cardiac repolarization and depolarization in people with Type 1 diabetes with normal ejection fraction and without known heart disease: a case\u2010control study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-1131","authenticated-orcid":false,"given":"J. 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