{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:22:12Z","timestamp":1791055332924,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Type 2 diabetes mellitus is associated with cognitive dysfunction, but the underlying structural brain correlates are uncertain. This study examined the association between cognitive functioning and structural brain abnormalities in people with long\u2010standing Type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010three people with Type 2 diabetes (age 62.3\u00a0\u00b1\u00a05.4\u00a0years, diabetes duration 9.7\u00a0\u00b1\u00a06.7 years; HbA<jats:sub>1c<\/jats:sub>65\u00a0\u00b1\u00a010\u00a0mmol\/mol, 8.1\u00a0\u00b1\u00a01.3%) were included. Cognitive functioning was assessed by a test battery covering the domains memory, processing speed and executive functioning. Brain tissue volumes and white matter hyperintensity volumes were automatically determined on<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. Linear regression analyses were performed adjusted for age, sex and education.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In people with Type 2 diabetes, increased white matter hyperintensity volume was associated with decreased processing speed [regression<jats:italic>B<\/jats:italic>coefficient\u00a0=\u00a0\u22120.22 (\u22120.38 to \u22120.06),<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009], but not with memory or executive function (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Brain tissue volumes were not significantly related to cognitive functioning (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In people with long\u2010standing, less strictly controlled Type 2 diabetes, white matter hyperintensities volumes were associated with decreased processing speed. This suggests that cerebral small vessel disease is an underlying disease mechanism of cognitive dysfunction in these individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13800","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T12:03:54Z","timestamp":1537358634000},"page":"1663-1670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Cognitive functioning and structural brain abnormalities in people with Type 2 diabetes mellitus"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-3604","authenticated-orcid":false,"given":"B.","family":"Mankovsky","sequence":"first","affiliation":[{"name":"Department of Diabetology National Medical Academy for Postgraduate Education Kiev Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Zherdova","sequence":"additional","affiliation":[{"name":"Department of Diabetology National Medical Academy for Postgraduate Education Kiev Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Neurology Rudolf Magnus Institute of Neuroscience Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.\u2010J.","family":"Biessels","sequence":"additional","affiliation":[{"name":"Department of Neurology Rudolf Magnus Institute of Neuroscience Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"de Bresser","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.02.054"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.5.661"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0023-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161194"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70284-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.10.024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.02.049"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390490514875"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.1999.00027.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160114"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617707070312"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0348"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1637"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12398"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161166"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0792-z"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0342"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.11.2048"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1239"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1923"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.060"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.04.06.db05-1323"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0143"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f25f06"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140702"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.07.002"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"12366","DOI":"10.1111\/jne.12366","article-title":"Altered hippocampal white matter connectivity in type 2 diabetes mellitus and memory decrements","volume":"28","author":"Bussel FC","year":"2016","journal-title":"J Neuroendocrinol"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.741"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321354"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0562"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.09.016"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617713001483"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-009-0416-2"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.13800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.13800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T14:00:42Z","timestamp":1720620042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.13800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/dme.13800"],"URL":"https:\/\/doi.org\/10.1111\/dme.13800","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]},"assertion":[{"value":"2018-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}