{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:26:21Z","timestamp":1788909981336,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 01GI0805\u201007"],"award-info":[{"award-number":["FKZ 01GI0805\u201007"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["633595 DynaHEALTH"],"award-info":[{"award-number":["633595 DynaHEALTH"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Children and adolescents with a family history of diabetes are at increased risk of overweight, but little is known about the potentially beneficial effects of physical activity on these children. The objective of this study was to investigate the association between moderate to vigorous physical activity (MVPA) and metabolic and inflammatory risks in children and adolescents with a family background of Type 1 diabetes or gestational diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Valid MVPA measurements, made with accelerometers, were available from 234 participants (median age, 10.2 years) who had a first\u2010degree relative with either Type 1 or gestational diabetes. Anthropometric and metabolic measurements were made and cytokines measured, and were correlated with MVPA measurements, with stepwise adjustment for confounding factors, in a cross\u2010sectional analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MVPA was negatively associated with insulin and C\u2010peptide during challenge with an oral glucose tolerance test. MVPA was also significantly positively associated with the insulin sensitivity index, whereas no consistently significant associations were found between MVPA and BMI, blood pressure or cytokine levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings indicate that physical activity may have beneficial effects on insulin and C\u2010peptide metabolism in children and adolescents with a family background of diabetes, but show no evidence of a protective association with other health\u2010related outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13819","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T13:15:21Z","timestamp":1537622121000},"page":"366-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Physical activity is associated with lower insulin and C\u2010peptide during glucose challenge in children and adolescents with family background of diabetes"],"prefix":"10.1111","volume":"36","author":[{"given":"K.","family":"Ungeth\u00fcm","sequence":"first","affiliation":[{"name":"Institute of Diabetes Research Helmholtz Zentrum M\u00fcnchen Neuherberg and Forschergruppe Diabetes der Technischen Universit\u00e4t M\u00fcnchen Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jolink","sequence":"additional","affiliation":[{"name":"Institute of Diabetes Research Helmholtz Zentrum M\u00fcnchen Neuherberg and Forschergruppe Diabetes der Technischen Universit\u00e4t M\u00fcnchen Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hippich","sequence":"additional","affiliation":[{"name":"Institute of Diabetes Research Helmholtz Zentrum M\u00fcnchen Neuherberg and Forschergruppe Diabetes der Technischen Universit\u00e4t M\u00fcnchen Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lachmann","sequence":"additional","affiliation":[{"name":"Institute of Diabetes Research Helmholtz Zentrum M\u00fcnchen Neuherberg and Forschergruppe Diabetes der Technischen Universit\u00e4t M\u00fcnchen Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Haupt","sequence":"additional","affiliation":[{"name":"Institute of Diabetes Research Helmholtz Zentrum M\u00fcnchen Neuherberg and Forschergruppe Diabetes der Technischen Universit\u00e4t M\u00fcnchen Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Winkler","sequence":"additional","affiliation":[{"name":"Institute of Diabetes Research Helmholtz Zentrum M\u00fcnchen Neuherberg and Forschergruppe Diabetes der Technischen Universit\u00e4t M\u00fcnchen Munich"},{"name":"Forschergruppe Diabetes e.V. am Helmholtz Zentrum M\u00fcnchen Neuherberg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hummel","sequence":"additional","affiliation":[{"name":"Institute of Diabetes Research Helmholtz Zentrum M\u00fcnchen Neuherberg and Forschergruppe Diabetes der Technischen Universit\u00e4t M\u00fcnchen Munich"},{"name":"Forschergruppe Diabetes e.V. am Helmholtz Zentrum M\u00fcnchen Neuherberg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pitchika","sequence":"additional","affiliation":[{"name":"Institute of Diabetes Research Helmholtz Zentrum M\u00fcnchen Neuherberg and Forschergruppe Diabetes der Technischen Universit\u00e4t M\u00fcnchen Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Kordonouri","sequence":"additional","affiliation":[{"name":"Kinder\u2010 und Jugendkrankenhaus AUF DER BULT Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010G.","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Institute of Diabetes Research Helmholtz Zentrum M\u00fcnchen Neuherberg and Forschergruppe Diabetes der Technischen Universit\u00e4t M\u00fcnchen Munich"},{"name":"Forschergruppe Diabetes e.V. am Helmholtz Zentrum M\u00fcnchen Neuherberg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6603-5036","authenticated-orcid":false,"given":"A.","family":"Beyerlein","sequence":"additional","affiliation":[{"name":"Institute of Diabetes Research Helmholtz Zentrum M\u00fcnchen Neuherberg and Forschergruppe Diabetes der Technischen Universit\u00e4t M\u00fcnchen Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.Global Report on Diabetes. 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