{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:34:28Z","timestamp":1761744868702,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Optimal treatment of cardiovascular disease is essential to decrease mortality among people with diabetes, but information is limited on how actual treatment relates to guidelines. We analysed changes in therapeutic approaches to anti\u2010hypertensive and lipid\u2010lowering medications in people with Type 2 diabetes from 2006 and 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Summary data from clinical services in seven countries outside North America and Western Europe were collected for 39\u00a0684 people. Each site summarized individual\u2010level data from outpatient medical records for 2006 and 2015. Data included: demographic information, blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>), total cholesterol levels and percentage of people taking statins, anti\u2010hypertensive medication (angiotensin\u2010converting enzyme inhibitors, calcium channel blockers, angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blockers, thiazide diuretics) and antiplatelet drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2006 to 2015, mean cholesterol levels decreased in six of eight sites (range: \u22120.5 to \u22120.2), whereas the proportion with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> levels &gt;\u00a0140\/90\u00a0mmHg increased in seven of eight sites. Decreases in cholesterol paralleled increases in statin use (range: 3.1 to 47.0 percentage points). Overall, utilization of anti\u2010hypertensive medication did not change.\u00a0However, there was an increase in the use of angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blockers and a decrease in angiotensin\u2010converting enzyme inhibitors. The percentage of individuals receiving calcium channel blockers and aspirin remained unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that control of cholesterol levels improved and coincided with increased use of statins. The percentage of people with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> &gt;\u00a0140\/90\u00a0mmHg was higher in 2015 than in 2006. Hypertension treatment shifted from using angiotensin\u2010converting enzyme inhibitors to angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blockers. Despite the potentially greater tolerability of angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blockers, there was no associated improvement in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13858","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T07:04:34Z","timestamp":1541574274000},"page":"878-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiovascular disease management in people with diabetes outside North America and Western Europe in 2006 and 2015"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3769-9666","authenticated-orcid":false,"given":"M.","family":"Tabesh","sequence":"first","affiliation":[{"name":"Baker Heart and Diabetes Institute Melbourne Australia"},{"name":"Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Magliano","sequence":"additional","affiliation":[{"name":"Baker Heart and Diabetes Institute Melbourne Australia"},{"name":"Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Tanamas","sequence":"additional","affiliation":[{"name":"Baker Heart and Diabetes Institute Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Surmont","sequence":"additional","affiliation":[{"name":"AstraZeneca London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bahendeka","sequence":"additional","affiliation":[{"name":"MKPGMS\u2010Uganda Martyrs University &amp; St. Francis Hospital Nsambya Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010E.","family":"Chiang","sequence":"additional","affiliation":[{"name":"General Clinical Research Center Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Elgart","sequence":"additional","affiliation":[{"name":"CENEXA. Centro de Endocrinolog\u00eda Experimental y Aplicada (UNLP\u2010CONICET) La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Gagliardino","sequence":"additional","affiliation":[{"name":"CENEXA. Centro de Endocrinolog\u00eda Experimental y Aplicada (UNLP\u2010CONICET) La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-121X","authenticated-orcid":false,"given":"S.","family":"Kalra","sequence":"additional","affiliation":[{"name":"Bharti Research Institute of Diabetes &amp; Endocrinology Bharti Hospital Karnal Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Dr A Ramachandran's Diabetes Hospitals Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-6069","authenticated-orcid":false,"given":"A.","family":"Luk","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Prince of Wales Hospital Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Maegawa","sequence":"additional","affiliation":[{"name":"Shiga University of Medical Science Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Motala","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology University of KwaZulu Natal Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pirie","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology University of KwaZulu Natal Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Dr A Ramachandran's Diabetes Hospitals Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tayeb","sequence":"additional","affiliation":[{"name":"Diabetes Center at AlNoor Specialist Hospital Makkah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Vikulova","sequence":"additional","affiliation":[{"name":"FGBU \u2018Endocrinology Research Center\u2019 Ministry of Health Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital Diabetes Centre and the University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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