{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T10:19:43Z","timestamp":1775989183473,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Novartis Pharma AG"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the long\u2010term clinical benefits of early combination treatment with vildagliptin\u2010metformin vs. standard\u2010of\u2010care, metformin monotherapy in the ongoing <jats:styled-content style=\"fixed-case\">VERIFY<\/jats:styled-content> study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We randomized 2001 participants with multi\u2010ethnic background, aged 18\u201370 years, having HbA<jats:sub>1c<\/jats:sub> levels 48\u201358 mmol\/mol (6.5\u20137.5%) and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 22\u201340 kg\/m<jats:sup>2<\/jats:sup>. Baseline data included HbA<jats:sub>1c<\/jats:sub>, fasting plasma glucose and homeostasis model \u03b2\u2010cell and insulin sensitivity. Standardized meal\u2010tests, insulin secretion rate relative to glucose, and oral glucose insulin sensitivity were assessed in a subpopulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 4524 screened, data were collected from the 2001 eligible participants (53% women) across Europe (52.4%), Latin America (26.8%), Asia (17.2%), South Africa (3.1%) and Australia (0.5%). The median (interquartile range) disease duration was 3.4 (0.9, 10.2) months; mean (\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) age 54.3\u00b19.4 years; weight 85.5\u00b117.5 kg and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 31.1\u00b14.7 kg\/m<jats:sup>2<\/jats:sup>. Baseline HbA<jats:sub>1c<\/jats:sub> was 52\u00b13 mmol\/mol (6.9\u00b10.3%), fasting plasma glucose 7.5\u00b11.5 mmol\/l and the median (interquartile range) of fasting insulin was 109 (75\u2013160) <jats:styled-content style=\"fixed-case\">mU<\/jats:styled-content>\/l. Homeostasis model \u03b2\u2010cell and insulin sensitivity values were 84% (60, 116) and 46% (31, 68), respectively. In those undertaking meal\u2010tests, insulin secretion rate relative to glucose was 28\u00b112 pmol\/min\/m<jats:sup>2<\/jats:sup>\/mmol\/l and oral glucose insulin sensitivity was 353\u00b157 ml\/min\/m<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our current, multi\u2010ethnic, newly diagnosed <jats:styled-content style=\"fixed-case\">VERIFY<\/jats:styled-content> population reflects a characteristic presence of early insulin resistance in participants with increased demand for insulin associated with obesity. The <jats:styled-content style=\"fixed-case\">VERIFY<\/jats:styled-content> study will provide unique evidence in characterizing therapeutic intervention in a diverse population with hyperglycaemia, focusing on durability of early glycaemic control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13886","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T21:58:09Z","timestamp":1545429489000},"page":"505-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Baseline characteristics in the VERIFY study: a randomized trial assessing the durability of glycaemic control with early vildagliptin\u2010metformin combination in newly diagnosed Type 2 diabetes"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6504-0036","authenticated-orcid":false,"given":"D. 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