{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:04:27Z","timestamp":1790823867809,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the association between skin advanced glycation end products and insulin resistance in Type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group consisted of 476 people with Type 1 diabetes (247 men) with a median (interquartile range) age of 42 (33\u201353) years, disease duration of 24 (19\u201332) years and HbA<jats:sub>1c<\/jats:sub> concentration of 63 (55\u201374) mmol\/mol [7.9 (7.2\u20138.9)%]. Insulin resistance was assessed according to estimated glucose disposal rate. Advanced glycation product accumulation in the skin was measured by autofluorescence using an <jats:styled-content style=\"fixed-case\">AGE<\/jats:styled-content> Reader. The group was divided into three subgroups based on estimated glucose disposal rate tertiles (&lt;5.5, 5.5\u20139.5 and &gt;9.5 mg\/kg\/min, respectively). The higher the estimated glucose disposal rate, the lower the insulin resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Skin autofluoresence level decreased with increasing estimated glucose disposal rate; comparing people below the lower tertile, with those between the first and third tertiles, and with those above the third tertile, the median autofluoresences were, respectively: 2.5 (2.2\u20132.9) vs 2.3 (2.0\u20132.7) vs 2.1 (1.9\u20132.5) <jats:styled-content style=\"fixed-case\">AU<\/jats:styled-content> (<jats:italic>P<\/jats:italic>&lt;0.0001). A negative correlation was observed between skin autofluorescence and estimated glucose disposal rate (Spearman's correlation coefficient=\u20130.31, <jats:italic>P<\/jats:italic> &lt;0.001). Multiple logistic regression showed a significant, two\u2010way association of insulin resistance with skin autofluorescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study offer strong evidence for a two\u2010way relationship between insulin resistance and advanced glycation product accumulation in the skin in people with Type 1 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13921","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T11:24:08Z","timestamp":1549020248000},"page":"620-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Accumulation of advanced glycation end products in the skin is accelerated in relation to insulin resistance in people with Type 1 diabetes 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