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Med."],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the appropriate fasting plasma glucose threshold by which to define prediabetes in children and adolescents, based on its ability to predict incident paediatric diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a nationwide survey of diabetes and renal disease conducted between 1992 and 2000 in all school\u2010aged children in Taiwan, those with abnormal results in repeated urine tests received further physical examination and blood tests. Students who had blood tests for at least two time points were selected for the present study (<jats:italic>N<\/jats:italic> = 12 119). The incidence of paediatric diabetes, adjusted hazard ratio and predictive power of fasting plasma glucose were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of paediatric diabetes increased with increasing fasting plasma glucose levels. Groups with fasting plasma glucose &gt;5.6 mmol\/l had a higher adjusted hazard ratio. The adjusted hazard ratio of incident diabetes for participants with higher fasting plasma glucose rose continuously when using a higher threshold for fasting plasma glucose. The area under the receiver\u2010operating characteristic curve for fasting plasma glucose was 0.628 for predicting paediatric diabetes. The association between fasting plasma glucose and incident paediatric diabetes and the area under the receiver\u2010operating characteristic curve were similar in boys and girls and were higher in the age group 12\u201318 years. According to receiver\u2010operating characteristic curve analysis, the optimal thresholds, sensitivity and specificity were 4.75 mmol\/l, 65% and 51%, respectively, for those aged 6\u201311 years and 5.19 mmol\/l, 60% and 73%, respectively, for those aged 12\u201318 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fasting plasma glucose is associated with the incidence of paediatric diabetes. The results of the present study can be used as reference data to suggest a cut\u2010off value to define paediatric prediabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13925","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T06:59:43Z","timestamp":1549436383000},"page":"633-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-8823","authenticated-orcid":false,"given":"C.\u2010Y.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Medical Imaging E\u2010Da Hospital Kaohsiung"},{"name":"School of Medicine for International Students I\u2010Shou University Kaohsiung"},{"name":"Department of Medical Imaging National Taiwan University Hospital and National Taiwan University College of Medicine Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-2855","authenticated-orcid":false,"given":"H.\u2010Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.\u2010C.","family":"Sung","sequence":"additional","affiliation":[{"name":"Institute of Environmental Health China Medical University College of Public Health Taichung"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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