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Med."],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of antibiotic therapy in osteomyelitis treatment among people with diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search of PubMed, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AMED<\/jats:styled-content>, Web of Science, the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> trial registry, Cochrane library databases, and ClinicalTrials.gov, in addition to hand\u2010searching, was undertaken in July 2018. Two reviewers independently extracted data. The studies\u2019 methodological quality was assessed using the modified Jadad scale. Descriptive analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven randomized controlled trials, with 393 participants in total, were included. The antibiotic regimens, treatments and follow\u2010up durations varied among the trials. The total scores showed that the overall methodological quality of the seven studies was high, despite two studies showing some flaws in double\u2010blinding and withdrawals\/drop\u2010outs. Of four studies comparing different antibiotic regimens, three implied a similar remission effect, while one implied that ertapenem \u00b1 vancomycin treatment showed a higher remission rate than tigecycline treatment; this conclusion was not robust because of low power and small sample size. In the other three studies, which included two different doses of ciprofloxacin, an antibiotics group and a conservative surgical group, and two durations of the same antibiotic strategy, no significant differences in remission were reported between the groups. No difference was observed in the analyses of microbiological outcomes, superinfections and relapse, except adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no definitive evidence supporting the superiority of any particular antibiotic agent, dose, or administration duration in the treatment of osteomyelitis in diabetes. As the included studies had some flaws and limitations, further research is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13935","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T17:15:35Z","timestamp":1550682935000},"page":"546-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Systematic review of randomized controlled trials on antibiotic treatment for osteomyelitis in diabetes"],"prefix":"10.1111","volume":"36","author":[{"given":"K.","family":"Xing","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Oncology Honghui Hospital Xi'an Jiaotong University College of Medicine Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology Honghui Hospital Xi'an Jiaotong University College of Medicine Xi'an Shaanxi 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