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Med."],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the effect of pump vs injection therapy on the lipid profile of children with Type 1 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional analysis of the lipid profile of children aged \u2264 18 years with Type 1 diabetes mellitus from <jats:styled-content style=\"fixed-case\">SWEET<\/jats:styled-content>, an international diabetes registry, was conducted with a focus on the effect of treatment regimen. Dyslipidaemia was defined as <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> cholesterol \u22652.6 mmol\/l or non\u2010<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol \u22653.1 mmol\/l. <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol values among 14 290 children (52% boys, 51% receiving pump therapy) from 60 <jats:styled-content style=\"fixed-case\">SWEET<\/jats:styled-content> centres were analysed by linear and logistic regression analysis adjusted for sex, age, diabetes duration, HbA<jats:sub>1c<\/jats:sub> and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2010standard deviation score group, region, and common interactions between age, sex, HbA<jats:sub>1c<\/jats:sub> and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study confirmed the established associations of increased lipids with female sex, age, diabetes duration, HbA<jats:sub>1c<\/jats:sub> and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol levels were lower in the pump therapy group compared to the injection therapy group [<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> cholesterol: injection therapy 2.44 mmol\/l (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.42 to 2.46) vs pump therapy 2.39 mmol\/l (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.37\u20132.41), <jats:italic>P<\/jats:italic>&lt;0.001; non\u2010<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol: injection therapy 2.88 mmol\/l (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.86 to 2.90) vs pump therapy 2.80 mmol\/l (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.78\u20132.82), both <jats:italic>P<\/jats:italic>&lt;0.0001]. Similarly, the odds ratios for <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> cholesterol \u22652.6 mmol\/l [0.89 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.82\u20130.97)] and non\u2010<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol \u22653.1 mmol\/l [0.85 (0.78 to 0.93)] were significantly lower in the pump therapy group, even after all adjustments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that pump therapy is associated with a better lipid profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.13963","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T23:01:05Z","timestamp":1555023665000},"page":"1294-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lipid profile is associated with treatment regimen in a large cohort of children and adolescents with Type 1 diabetes mellitus: a study from the international <scp>SWEET<\/scp> database"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-4884","authenticated-orcid":false,"given":"I.","family":"Kosteria","sequence":"first","affiliation":[{"name":"Diabetes Centre, Division of Endocrinology, Diabetes and Metabolism First Department of Paediatrics National and Kapodistrian University of Athens Medical School, Aghia Sophia Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3041-0759","authenticated-orcid":false,"given":"A.","family":"Schwandt","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry ZIBMT Ulm University Ulm Germany"},{"name":"German Centre for Diabetes Research Munich\u2010Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Centre for Child Health Research Telethon Kids Institute University of Western Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jali","sequence":"additional","affiliation":[{"name":"J. 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