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Med."],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate potential cost savings associated with the use of real\u2010time continuous glucose monitoring (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CGM<\/jats:styled-content>) throughout pregnancy in women with Type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A budget impact model was developed to estimate, from the perspective of National Health Service England, the total costs of managing pregnancy and delivery in women with Type 1 diabetes using self\u2010monitoring of blood glucose (<jats:styled-content style=\"fixed-case\">SMBG<\/jats:styled-content>) with and without <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CGM<\/jats:styled-content>. It was assumed that the entire modelled cohort (<jats:italic>n<\/jats:italic> = 1441) would use <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CGM<\/jats:styled-content> from 10 to 38 weeks\u2019 gestation (7 months). Data on pregnancy and neonatal complication rates and related costs were derived from published literature, national tariffs, and device manufacturers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cost of glucose monitoring was \u00a3588 with <jats:styled-content style=\"fixed-case\">SMBG<\/jats:styled-content> alone and \u00a31820 with <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CGM<\/jats:styled-content>. The total annual costs of managing pregnancy and delivery in women with Type 1 diabetes were \u00a323\u00a0725\u00a0648 with <jats:styled-content style=\"fixed-case\">SMBG<\/jats:styled-content> alone, and \u00a314\u00a0165\u00a0187 with <jats:styled-content style=\"fixed-case\">SMBG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CGM<\/jats:styled-content>; indicating potential cost savings of approximately \u00a39\u00a0560\u00a0461 from using <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CGM<\/jats:styled-content>. The principal drivers of cost savings were the daily cost of neonatal intensive care unit (<jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content>) admissions (\u00a33743) and the shorter duration of <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> stay (mean 6.6 vs. 9.1 days respectively). Sensitivity analyses showed that <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CGM<\/jats:styled-content> remained cost saving, albeit to lesser extents, across a range of <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> costs and durations of hospital stay, and with varying numbers of daily <jats:styled-content style=\"fixed-case\">SMBG<\/jats:styled-content> measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Routine use of <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CGM<\/jats:styled-content> by pregnant women with Type 1 diabetes, would result in substantial cost savings, mainly through reductions in <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> admissions and shorter duration of <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14046","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T17:09:06Z","timestamp":1559668146000},"page":"1652-1658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Modelling potential cost savings from use of real\u2010time continuous glucose monitoring in pregnant women with Type 1 diabetes"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-8727","authenticated-orcid":false,"given":"H. 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