{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:14:13Z","timestamp":1767093253290,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify groups of heterogeneous HbA<jats:sub>1c<\/jats:sub> trajectories over time in newly diagnosed Type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study comprised 6355 adults with newly diagnosed Type 2 diabetes (55% men, median age 62 years, baseline <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 31 kg\/m<jats:sup>2<\/jats:sup>) from the <jats:italic>Diabetes Patienten Verlaufsdokumentation<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">DPV<\/jats:styled-content><\/jats:italic>) prospective multicentre diabetes registry (Germany, Austria). Individuals were assessed during the first 5 years after diabetes diagnosis if they had \u2265 3 aggregated HbA<jats:sub>1c<\/jats:sub> measurements during follow\u2010up. Latent class growth modelling was used to determine distinct subgroups that followed similar longitudinal HbA<jats:sub>1c<\/jats:sub> patterns (<jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content>: Proc Traj). Multinomial logistic regression models were used to investigate which variables were associated with the respective HbA<jats:sub>1c<\/jats:sub> trajectory groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four distinct longitudinal HbA<jats:sub>1c<\/jats:sub> trajectory (glycaemic control) groups were found. The largest group (56% of participants) maintained stable good glycaemic control (HbA<jats:sub>1c<\/jats:sub> 42\u201345 mmol\/mol). Twenty\u2010six percent maintained stable moderate glycaemic control (HbA<jats:sub>1c<\/jats:sub> 57\u201362 mmol\/mol). A third group (12%) initially showed severe hyperglycaemia (HbA<jats:sub>1c<\/jats:sub> 97 mmol\/mol) but reached good glycaemic control within 1 year. The smallest group (6%) showed stable poor glycaemic control (HbA<jats:sub>1c<\/jats:sub> 79\u201388 mmol\/mol). Younger age at diabetes diagnosis, male sex, and higher <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> were associated with the stable moderate or poor glycaemic control groups. Insulin therapy was strongly associated with the highly improved glycaemic control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Four subgroups with distinct HbA<jats:sub>1c<\/jats:sub> trajectories were determined in newly diagnosed Type 2 diabetes using a group\u2010based modelling approach. Approximately one\u2010third of people with newly diagnosed Type 2 diabetes need either better medication adherence or earlier intensification of glucose\u2010lowering therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14103","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T01:23:24Z","timestamp":1565227404000},"page":"1468-1477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Distinct trajectories of HbA<sub>1c<\/sub> in newly diagnosed Type 2 diabetes from the <i><scp>DPV<\/scp><\/i> registry using a longitudinal group\u2010based modelling approach"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7804-1740","authenticated-orcid":false,"given":"W.","family":"Rathmann","sequence":"first","affiliation":[{"name":"Institute of Biometrics and Epidemiology German Diabetes Centre Leibniz Centre for Diabetes Research at Heinrich Heine University D\u00fcsseldorf Germany"},{"name":"German Centre for Diabetes Research (DZD) M\u00fcnchen\u2010Neuherberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3041-0759","authenticated-orcid":false,"given":"A.","family":"Schwandt","sequence":"additional","affiliation":[{"name":"German Centre for Diabetes Research (DZD) M\u00fcnchen\u2010Neuherberg Germany"},{"name":"Institute of Epidemiology and Medical Biometry ZIBMT Ulm University Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-1163","authenticated-orcid":false,"given":"J. M.","family":"Hermann","sequence":"additional","affiliation":[{"name":"German Centre for Diabetes Research (DZD) M\u00fcnchen\u2010Neuherberg Germany"},{"name":"Institute of Epidemiology and Medical Biometry ZIBMT Ulm University Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Kuss","sequence":"additional","affiliation":[{"name":"Institute of Biometrics and Epidemiology German Diabetes Centre Leibniz Centre for Diabetes Research at Heinrich Heine University D\u00fcsseldorf Germany"},{"name":"German Centre for Diabetes Research (DZD) M\u00fcnchen\u2010Neuherberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Roden","sequence":"additional","affiliation":[{"name":"German Centre for Diabetes Research (DZD) M\u00fcnchen\u2010Neuherberg Germany"},{"name":"Institute for Clinical Diabetology German Diabetes Centre Leibniz Centre for Diabetes Research at Heinrich Heine University D\u00fcsseldorf Germany"},{"name":"Department of Endocrinology and Diabetology Medical Faculty Heinrich Heine University D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Laubner","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology Department of Medicine II Medical Centre University of Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Best","sequence":"additional","affiliation":[{"name":"Diabetes Practice Dr. Best Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ebner","sequence":"additional","affiliation":[{"name":"Medical Campus III Clinic for Internal Medicine 2 Kepler University Hospital Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Plaumann","sequence":"additional","affiliation":[{"name":"Specialist Diabetes Practice Hannover Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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