{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:58:15Z","timestamp":1779177495023,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the incretin axis in people with cystic fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults with cystic fibrosis\u2010related diabetes, cystic fibrosis without diabetes, and controls (adults without cystic fibrosis and without diabetes) underwent an oral glucose tolerance test and then a closely matched isoglycaemic i.v. glucose infusion. On each occasion, glucose, insulin, C\u2010peptide, total and active glucagon\u2010like peptide\u20101 and gastric inhibitory polypeptide responses were recorded and incremental areas under curves were calculated for 60 and 240 min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five adults with cystic fibrosis\u2010related diabetes, six with cystic fibrosis without diabetes and six controls, matched for age and BMI, completed the study. Glucose during oral glucose tolerance test closely matched those during isoglycaemic i.v. glucose infusion. The calculated incretin effect was similar in the control group and the cystic fibrosis without diabetes group (28% and 29%, respectively), but was lost in the cystic fibrosis\u2010related diabetes group (cystic fibrosis\u2010related diabetes vs control group: \u20136% vs 28%; <jats:italic>p<\/jats:italic>=0.03). No hyposecretion of glucagon\u2010like peptide\u20101 or gastric inhibitory polypeptide was observed; conversely, 60\u2010min incremental area under the curve for total glucagon\u2010like peptide\u20101 was significantly higher in the cystic fibrosis\u2010related diabetes group than in the control group [1070.4 (254.7) vs 694.97 (308.1); <jats:italic>p=<\/jats:italic>0.03]<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incretin effect was lost in cystic fibrosis\u2010related diabetes despite adequate secretion of the incretin hormones. These data support the concept that reduced incretin hormone insulinotropic activity contributes significantly to postprandial hyperglycaemia in cystic fibrosis\u2010related diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14121","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T22:43:43Z","timestamp":1567118623000},"page":"1367-1374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Loss of incretin effect contributes to postprandial hyperglycaemia in cystic fibrosis\u2010related diabetes"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-6502","authenticated-orcid":false,"given":"F.","family":"Frost","sequence":"first","affiliation":[{"name":"Adult CF Centre Liverpool Heart and Chest NHS Foundation Trust Liverpool UK"},{"name":"Institute of Infection and Global Health University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. H.","family":"Jones","sequence":"additional","affiliation":[{"name":"Adult CF Centre Liverpool Heart and Chest NHS Foundation Trust Liverpool UK"},{"name":"Royal Liverpool and Broadgreen University NHS Foundation Trust Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Dyce","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Related Diabetes Service Liverpool Heart and Chest NHS Foundation Trust Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Related Diabetes Service Liverpool Heart and Chest NHS Foundation Trust Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Nazareth","sequence":"additional","affiliation":[{"name":"Adult CF Centre Liverpool Heart and Chest NHS Foundation Trust Liverpool UK"},{"name":"Institute of Infection and Global Health University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Walshaw","sequence":"additional","affiliation":[{"name":"Adult CF Centre Liverpool Heart and Chest NHS Foundation Trust Liverpool UK"},{"name":"Institute of Infection and Global Health University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00482-9"},{"key":"e_1_2_8_3_1","first-page":"145","article-title":"Endocrine complications of cystic fibrosis","volume":"13","author":"Moran A","year":"2002","journal-title":"Adolesc Med"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1279"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13652"},{"key":"e_1_2_8_6_1","volume-title":"Cystic fibrosis related diabetes: Section 1723","author":"NICE","year":"2017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.05.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.03.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1492"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-2-20"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02427280"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198411000-00011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.26.6.525"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1899"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.11.2497"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.380"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80191-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0394"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1611"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1542\/peds.67.2.252","article-title":"Hypersecretion of gastric inhibitory polypeptide in nondiabetic children with cystic fibrosis","volume":"67","author":"Ross SA","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4417"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(83)80021-3"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90370-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1280207"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-017-0015-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1275270"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2011.11.001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0342-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13544"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1124"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2435"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.14121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dme.14121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.14121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T02:27:41Z","timestamp":1694140061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.14121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,17]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/dme.14121"],"URL":"https:\/\/doi.org\/10.1111\/dme.14121","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,17]]},"assertion":[{"value":"2019-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}