{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:58:23Z","timestamp":1747184303136,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To revisit the data analysis used to inform National Institute of Health and Care Excellence (NICE) NG17 guidance for initiating basal insulin in adults with type 1 diabetes mellitus (diabetes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We replicated the data, methodology and analysis used by NICE diabetes in the NG17 network meta\u2010analysis (NMA). We expanded this data cohort to a more contemporary data set (extended 2017 NMA) and restricted the studies included to improve the robustness of the data set (restricted 2017 NMA) and in a <jats:italic>post hoc<\/jats:italic> analysis, changed the index comparator from neutral protamine Hagedorn (NPH) insulin twice daily to insulin detemir twice daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The absolute changes in HbA<jats:sub>1c<\/jats:sub> were similar to those reported in the NG17. However, all 95% credible intervals for change in HbA<jats:sub>1c<\/jats:sub> point estimates crossed the line of null effect, except for detemir twice daily (in the NICE and extended 2017 NMAs) and NPH four times daily. In the detemir twice\u2010daily centred <jats:italic>post hoc<\/jats:italic> analysis, the 95% credible intervals for change in HbA<jats:sub>1c<\/jats:sub> crossed the line of null effect for all basal therapies, except NPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In NG17, comparisons of basal insulins were based solely on efficacy of glycaemic control. Many of the trials used in this analysis were treat\u2010to\u2010target, which minimize differences in HbA<jats:sub>1c<\/jats:sub>. In the NMAs, statistical significance was severely undermined by the wide credible intervals. Despite these limitations, point estimates of HbA<jats:sub>1c<\/jats:sub> were used to rank the insulins and formed the basis of NG17 guidance. This study queries whether such analyses should be used to make specific clinical recommendations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14180","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:11:17Z","timestamp":1573816277000},"page":"219-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A review of the NG17 recommendations for the use of basal insulin in type 1 diabetes"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8519-4964","authenticated-orcid":false,"given":"S.","family":"Bain","sequence":"first","affiliation":[{"name":"Diabetes Research Unit Cymru University Medical School Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Feher","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Surrey Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Pharmacology Glasgow Royal Infirmary Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-9429","authenticated-orcid":false,"given":"N.","family":"Hex","sequence":"additional","affiliation":[{"name":"York Health Economics Consortium Ltd University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. C. S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Sanofi Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mahon","sequence":"additional","affiliation":[{"name":"York Health Economics Consortium Ltd University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Russell\u2010Jones","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Royal Surrey County Hospital and University of Surrey Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Schou","sequence":"additional","affiliation":[{"name":"Sanofi Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-6207","authenticated-orcid":false,"given":"E. G.","family":"Wilmot","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology University Hospitals of Derby and Burton NHS FT Derby UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Sanofi Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"volume-title":"Type 1 Diabetes in Adults: Diagnosis and Management","year":"2015","author":"National Institute of Health and Care Excellence","key":"e_1_2_10_2_1"},{"volume-title":"About the IQVIA CORE Diabetes Model","year":"2018","author":"IQVIA","key":"e_1_2_10_3_1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13062"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13026"},{"volume-title":"Type 1 Diabetes in Adults: Diagnosis and Management","author":"National Institute of Health and Care Excellence","key":"e_1_2_10_6_1"},{"volume-title":"Type 1 Diabetes: Diagnosis and Management","author":"National Institute of Health and Care Excellence","key":"e_1_2_10_7_1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13048"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12619"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0684"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7115"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12573"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1081"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1365-z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01862.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2011.0063"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1925"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03547.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.572"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094483"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0098"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.590"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2006.11.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01545.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2004.6.579"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.11.1666"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.296"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02407.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12806"},{"volume-title":"Diabetes (Type 1 and Type 2) in Children and Young People: Diagnosis and Management","year":"2015","author":"National Institute of Health and Care Excellence","key":"e_1_2_10_30_1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.04.024"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.14180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dme.14180","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.14180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:53:47Z","timestamp":1694166827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.14180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,27]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/dme.14180"],"URL":"https:\/\/doi.org\/10.1111\/dme.14180","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"type":"print","value":"0742-3071"},{"type":"electronic","value":"1464-5491"}],"subject":[],"published":{"date-parts":[[2019,11,27]]},"assertion":[{"value":"2019-11-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}