{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:46:12Z","timestamp":1784115972442,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the characteristics of children and adolescents with type 1 vs. type 2 diabetes in the Pediatric Diabetes Consortium (PDC) registries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were 10 to &lt;\u00a021 years of age at diagnosis; there were 484 with type 1 diabetes and 1236 with type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children and adolescents with type 2 diabetes were more likely to be female, overweight\/obese, and from low\u2010income, minority ethnic families. Children and adolescents with type 1 diabetes were more likely to present with diabetic ketoacidosis and have higher mean HbA<jats:sub>1c<\/jats:sub> levels at diagnosis. More than 70% in both cohorts achieved target HbA<jats:sub>1c<\/jats:sub> levels &lt;\u00a058\u00a0mmol\/mol (&lt;\u00a07.5%) within 6 months, but fewer participants with type 1 than type 2 diabetes were able to maintain target HbA<jats:sub>1c<\/jats:sub> levels after 6 months consistently throughout 3 years post diagnosis. Of the 401 participants with type 2 diabetes with \u2265\u00a024 months diabetes duration on enrolment in the registry, 47% required no insulin treatment. Median C\u2010peptide levels were 1.43\u00a0mmol\/l in the subset of participants with type 2 diabetes in whom it was measured, but only 0.06 mmol\/l in the subset with type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although families of children and adolescents with type 2 diabetes face greater socio\u2010economic obstacles and risk factors for poor diabetes outcomes, the greater retention of residual endogenous insulin secretion likely contributes to the increased ability of children and adolescents with type 2 diabetes to maintain target HbA<jats:sub>1c<\/jats:sub> during the first 3 years of diabetes diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14233","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T17:15:10Z","timestamp":1579022110000},"page":"863-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Children and adolescents with type 1 and type 2 diabetes mellitus in the Pediatric Diabetes Consortium Registries: comparing clinical characteristics and glycaemic control"],"prefix":"10.1111","volume":"37","author":[{"given":"M. A.","family":"Van Name","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Jaeb Center for Health Research Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-5383","authenticated-orcid":false,"given":"R. L.","family":"Gal","sequence":"additional","affiliation":[{"name":"Jaeb Center for Health Research Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kollman","sequence":"additional","affiliation":[{"name":"Jaeb Center for Health Research Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lynch","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Nelson","sequence":"additional","affiliation":[{"name":"School of Medicine\u2010Greenville University of South Carolina Greenville SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. V.","family":"Tamborlane","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Pediatric Diabetes Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2010.0065"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12068"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12377"},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"CDC growth charts: United States","volume":"314","author":"Kuczmarski R","year":"2000","journal-title":"Adv Data"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12280"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12763"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12281"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12459"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0078"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2011.00846.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12271"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.14233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.14233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dme.14233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.14233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T18:59:08Z","timestamp":1694026748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.14233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/dme.14233"],"URL":"https:\/\/doi.org\/10.1111\/dme.14233","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,5]]},"assertion":[{"value":"2020-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}