{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:59:19Z","timestamp":1791021559726,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006304","name":"Aalborg Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the trends in non\u2010traumatic lower limb amputation in people with and without diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From the Danish National Patient Register, all people with either type 1 or type 2 diabetes (n = 462 743) as well as a group of people without diabetes from the general population (n = 1 388 886) were identified and separated into three groups based on diabetes type. Among these, 17 265 amputations were identified between 1997 and 2017 and stratified into trans\u2010femoral amputations, trans\u2010tibial amputations and amputations below the ankle using surgical codes. Annual changes were described using least\u2010squares linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The yearly mean decrease in incidence rate of amputation per 1000 person\u2010years was \u22120.032 [95% CI: \u22120.062, \u22120.001], \u22120.022 [\u22120.032, \u22120.012] and \u22120.006 [\u22120.009, \u22120.003] for trans\u2212femoral amputation, \u22120.072 [\u22120.093, \u22120.052], \u22120.090 [\u22120.102, \u22120.078] and \u22120.015 [\u22120.016, \u22120.013] for trans\u2010tibial amputation, and \u22120.055 [\u22120.080, \u22120.020], \u22120.075 [\u22120.090, \u22120.060] and \u22120.011 [\u22120.014, \u22120.007] for amputation below the ankle in people with type 1 diabetes, people with type 2 diabetes and people without diabetes, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over recent decades, the incidence of amputation has decreased significantly in people with diabetes and in the general population without diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.14251","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T15:28:03Z","timestamp":1580225283000},"page":"2098-2108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Twenty years with diabetes and amputations: a retrospective population\u2010based cohort study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4578-1328","authenticated-orcid":false,"given":"J.","family":"R\u00f8ikjer","sequence":"first","affiliation":[{"name":"Steno Diabetes Center North Denmark Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-8644","authenticated-orcid":false,"given":"M. H.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine and Endocrinology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. V. 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