{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:52:19Z","timestamp":1780703539037,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CIRG\/1398\/2014."],"award-info":[{"award-number":["NMRC\/CIRG\/1398\/2014."]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/PPG\/AH(KTPH)\/2011"],"award-info":[{"award-number":["NMRC\/PPG\/AH(KTPH)\/2011"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association between baseline plasma zinc\u2010\u03b12\u2010glycoprotein and non\u2010albuminuric chronic kidney disease progression in type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults with normoalbuminuria at entry (<jats:italic>n<\/jats:italic>=341; age 57\u00b110 years, 52% men) were analysed. Chronic kidney disease progression was defined as a decrease in chronic kidney disease stage and a decline of \u226525% in estimated GFR from baseline. Baseline plasma zinc\u2010\u03b12\u2010glycoprotein levels were quantified by immunoassay, and analysed either as a continuous variable or by tertiles in Cox proportional hazards models. Model discrimination was assessed using Harrell's C\u2010index. A sensitivity analysis was performed on a subset of individuals who maintained normoalbuminuria during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic kidney disease progression occurred in 54 participants (16%). Zinc\u2010\u03b12\u2010glycoprotein levels were elevated in chronic kidney disease progressors (<jats:italic>P<\/jats:italic> = 0.011), and more progressors were assigned to the higher zinc\u2010\u03b12\u2010glycoprotein tertile than non\u2010progressors. In the unadjusted Cox model, zinc\u2010\u03b12\u2010glycoprotein, both as a continuous variable (hazard ratio 1.72, 95% CI 1.08\u20132.75) and tertile 3 (vs tertile 1; hazard ratio 2.14, 95% CI 1.10\u20134.17), predicted chronic kidney disease progression. The association persisted after multivariable adjustment. The C\u2010index of the Cox model increased significantly after incorporation of zinc\u2010\u03b12\u2010glycoprotein into a base model comprising renin\u2010angiotensin system antagonist usage. Sensitivity analysis showed that zinc\u2010\u03b12\u2010glycoprotein independently predicted chronic kidney disease progression among individuals who maintained normoalbuminuria during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Plasma zinc\u2010\u03b12\u2010glycoprotein is associated with chronic kidney disease progression, and may serve as a useful early biomarker for predicting non\u2010albuminuric chronic kidney disease progression in type 2 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14313","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T21:19:43Z","timestamp":1588281583000},"page":"1919-1926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Zinc\u2010\u03b12\u2010glycoprotein is associated with non\u2010albuminuric chronic kidney disease progression in type 2 diabetes: a retrospective study with 4\u2010year follow\u2010up"],"prefix":"10.1111","volume":"37","author":[{"given":"A.","family":"Moh","sequence":"first","affiliation":[{"name":"Clinical Research Unit Khoo Teck Puat Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Seah","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Khoo Teck Puat Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Low","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Khoo Teck Puat Hospital Singapore"},{"name":"Diabetes Centre Admiralty Medical Centre Khoo Teck Puat Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ang","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Khoo Teck Puat Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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