{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:18:15Z","timestamp":1792268295024,"version":"4.4.0"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare diagnosis characteristics, diabetes management and comorbidities in a population diagnosed with type 1 diabetes in childhood with those in a similar population diagnosed in adulthood to identify disease differences related to the age of diabetes onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This analysis was performed using the T1D Exchange Clinic Registry, a cross\u2010sectional survivor cohort. Retrospectively collected characteristics were compared across the following age\u2010at\u2010diagnosis groups: &lt;10, 10\u201317, 18\u201324, 25\u201339 and \u226540 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The entire cohort included 20 660 participants [51% female, median (interquartile range) age 18 (14\u201336) years, 82% non\u2010Hispanic white]. Diabetic ketoacidosis at diagnosis was more common among those with onset in childhood. Participants diagnosed as adults were more likely to be overweight\/obese at diagnosis and to have used oral agents preceding type 1 diabetes diagnosis (57%). Current insulin pump use was less frequent in participants diagnosed at older ages. Current glycaemic control, measured by HbA<jats:sub>1c<\/jats:sub>, insulin requirements and use of a continuous glucose monitor were not different by age at diagnosis. Coeliac disease was the only comorbidity that was observed to have a different frequency by age at diagnosis, being more common in the participants diagnosed at a younger age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results show differences and similarities between type 1 diabetes diagnosed in childhood vs adulthood; notably, there was a tendency for there was a higher frequency of diabetic ketoacidosis at onset in children and a higher frequency of use of oral antidiabetes agents in adults. The data indicate that there is little distinction between the clinical characteristics and outcomes of type 1 diabetes diagnosed in childhood vs adulthood. Optimizing glycaemic control remains a challenge in all age groups, with lower use of insulin pumps impacting those diagnosed as adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14314","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T21:18:47Z","timestamp":1588281527000},"page":"2109-2115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Characteristics of adult\u2010 compared to childhood\u2010onset type 1 diabetes"],"prefix":"10.1111","volume":"37","author":[{"given":"A.","family":"Casu","sequence":"first","affiliation":[{"name":"AdventHealth Translational Research Institute Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-5168","authenticated-orcid":false,"given":"L. G.","family":"Kanapka","sequence":"additional","affiliation":[{"name":"Jaeb Centre for Health Research Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-6977","authenticated-orcid":false,"given":"N. C.","family":"Foster","sequence":"additional","affiliation":[{"name":"Jaeb Centre for Health Research Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. B.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-492X","authenticated-orcid":false,"given":"L. M.","family":"Laffel","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Centre Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Barbara Davis Centre for Diabetes University of Colorado Anschutz Medical Campus Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"DeSalvo","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-0112","authenticated-orcid":false,"given":"S. K.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Vendrame","sequence":"additional","affiliation":[{"name":"University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Aleppo","sequence":"additional","affiliation":[{"name":"Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. D.","family":"Mastrandrea","sequence":"additional","affiliation":[{"name":"University at Buffalo Jacobs School of Medicine Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E.","family":"Pratley","sequence":"additional","affiliation":[{"name":"AdventHealth Translational Research Institute Orlando FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Rickels","sequence":"additional","affiliation":[{"name":"Rodebaugh Diabetes Centre University of Pennsylvania Perelman School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Peters","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of the University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the T1D Exchange Clinic Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0958-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S002"},{"key":"e_1_2_8_4_1","volume-title":"Type 1 Diabetes in Adults: Diagnosis and Management","author":"Centre","year":"2015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0931"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4863-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1561"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0078"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681300700418"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020904"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2018.1547711"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1952"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.14314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.14314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dme.14314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.14314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T01:33:49Z","timestamp":1693618429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.14314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,21]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/dme.14314"],"URL":"https:\/\/doi.org\/10.1111\/dme.14314","archive":["Portico"],"relation":{},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,21]]},"assertion":[{"value":"2020-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}