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Med."],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To present the longer\u2010term impact of multifactorial treatment of type 2 diabetes on self\u2010reported health status, diabetes\u2010specific quality of life, and diabetes treatment satisfaction at 10\u2010year follow up of the ADDITION\u2010Europe trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The ADDITION\u2010Europe trial enrolled 3057 individuals with screen\u2010detected type 2 diabetes from four centres [Denmark, the UK (Cambridge and Leicester) and the Netherlands], between 2001 and 2006. Participants were randomized at general practice level to intensive treatment or to routine care . The trial ended in 2009 and a 10\u2010year follow\u2010up was performed at the end of 2014. We measured self\u2010reported health status (36\u2010item Short\u2010Form Health Survey and EQ\u20105D), diabetes\u2010specific quality of life (Audit of Diabetes\u2010Dependent Quality of Life questionnaire), and diabetes treatment satisfaction (Diabetes Treatment Satisfaction Questionnaire) at different time points during the study period. A mixed\u2010effects model was applied to estimate the effect of intensive treatment (intention\u2010to\u2010treat analyses) on patient\u2010reported outcome measures for each centre. Centre\u2010specific estimates were pooled using a fixed effects meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in patient\u2010reported outcome measures between the routine care and intensive treatment arms in this 10\u2010year follow\u2010up study [EQ\u20105D: \u20130.01 (95% CI \u20130.03, 0.01); Physical Composite Score (36\u2010item Short\u2010Form Health Survey): \u20130.27 (95% CI \u20131.11, 0.57), Audit of Diabetes\u2010Dependent Quality of Life questionnaire: \u20130.01 (95% CI \u20130.11, 0.10); and Diabetes Treatment Satisfaction Questionnaire: \u20130.20 (95% CI \u20130.70, 0.29)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intensive, multifactorial treatment of individuals with screen\u2010detected type 2 diabetes did not affect self\u2010reported health status, diabetes\u2010specific quality of life, or diabetes treatment satisfaction at 10\u2010year follow\u2010up compared to routine care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14342","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T16:01:48Z","timestamp":1591977708000},"page":"1509-1518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patient\u2010reported outcomes after 10\u2010year follow\u2010up of intensive, multifactorial treatment in individuals with screen\u2010detected type 2 diabetes: the ADDITION\u2010Europe trial"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2115-7480","authenticated-orcid":false,"given":"E.\u2010M.","family":"Dalsgaard","sequence":"first","affiliation":[{"name":"Department of Public Health Aarhus University Aarhus Denmark"},{"name":"Steno Diabetes Centre Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sandb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Public Health Aarhus University Aarhus Denmark"},{"name":"Steno Diabetes Centre Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Griffin","sequence":"additional","affiliation":[{"name":"MRC Epidemiology Unit Institute of Metabolic Science School of Clinical Medicine University of Cambridge Cambridge UK"},{"name":"Primary Care Unit Institute of Public Health School of Clinical Medicine University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. E. H. M.","family":"Rutten","sequence":"additional","affiliation":[{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-7099","authenticated-orcid":false,"given":"K.","family":"Khunti","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester Leicester General Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-9371","authenticated-orcid":false,"given":"M. J.","family":"Davies","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester Leicester General Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"Irving","sequence":"additional","affiliation":[{"name":"Primary Care Unit Institute of Public Health School of Clinical Medicine University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. C.","family":"Vos","sequence":"additional","affiliation":[{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht University Utrecht The Netherlands"},{"name":"Department of Public Health and Primary Care\/LUMC\u2010Campus The Hague Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Webb","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester Leicester General Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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