{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:55:40Z","timestamp":1792155340770,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T00:00:00Z","timestamp":1596326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet. Med."],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Poor glucose control is associated with adverse outcomes in pregnancies with pre\u2010existing diabetes. However, strict glucose control increases the risk of severe hypoglycaemia, particularly in the first trimester. Therefore, we aimed to investigate whether less tight glucose control in the first trimester determines adverse outcomes or can be compensated for by good control in late pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective data were collected from 517 singleton pregnancies complicated by pre\u2010existing diabetes delivering between 2010 and 2017. Three hundred and thirty\u2010six pregnancies fulfilled the inclusion criteria of having available HbA\n                      <jats:sub>1c<\/jats:sub>\n                      values either pre\u2010conception or in the first trimester (65% type 1 diabetes, 35% type 2 diabetes).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher HbA\n                      <jats:sub>1c<\/jats:sub>\n                      values in the first trimester were associated with increasing rates of large for gestational age (LGA) neonates, preterm delivery or neonatal intensive care unit admissions. Multiple regression analysis demonstrated third trimester HbA\n                      <jats:sub>1c<\/jats:sub>\n                      , type 1 diabetes, multiparity and excess weight gain, but not first trimester HbA\n                      <jats:sub>1c<\/jats:sub>\n                      , to be independently predictive for LGA. Pre\u2010eclampsia and third trimester HbA\n                      <jats:sub>1c<\/jats:sub>\n                      increased the risk for preterm delivery. If HbA\n                      <jats:sub>1c<\/jats:sub>\n                      was \u2264 42 mmol\/mol (6.0%) in the third trimester, rates of adverse outcomes were not significantly higher even if HbA\n                      <jats:sub>1c<\/jats:sub>\n                      targets of \u2264 48 mmol\/mol (6.5%) had not been met in the first trimester. Good first trimester glucose control did not modify the rates of adverse outcomes if HbA\n                      <jats:sub>1c<\/jats:sub>\n                      was &gt;\u00a042 mmol\/mol (6.0%) in the third trimester.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Less tight glycaemic control, for example due to high frequency of severe hypoglycaemia in the first trimester, does not lead to increased adverse neonatal events if followed by tight control in the third trimester. Besides glycaemic control, excess weight gain is a modifiable predictor of adverse outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dme.14350","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T02:50:33Z","timestamp":1593053433000},"page":"1490-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Need for less tight glucose control in early pregnancy after embryogenesis due to high risk of maternal hypoglycaemia in women with pre\u2010existing diabetes can be compensated by good control in late pregnancy"],"prefix":"10.1111","volume":"37","author":[{"given":"F.","family":"Hauffe","sequence":"first","affiliation":[{"name":"Berlin Center for Diabetes and Pregnancy Department of Obstetrics and Gynaecology St. Joseph Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Fauzan","sequence":"additional","affiliation":[{"name":"Berlin Center for Diabetes and Pregnancy Department of Obstetrics and Gynaecology St. Joseph Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Schohe","sequence":"additional","affiliation":[{"name":"Berlin Center for Diabetes and Pregnancy Department of Obstetrics and Gynaecology St. Joseph Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Scholle","sequence":"additional","affiliation":[{"name":"Berlin Center for Diabetes and Pregnancy Department of Obstetrics and Gynaecology St. Joseph Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sedlacek","sequence":"additional","affiliation":[{"name":"Berlin Center for Diabetes and Pregnancy Department of Obstetrics and Gynaecology St. Joseph Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Scherer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Campus Rudolf\u2010Virchow, Charit\u00e9 Humboldt\u2010University Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Klapp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Campus Rudolf\u2010Virchow, Charit\u00e9 Humboldt\u2010University Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ramsauer","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics Clinicum Vivantes Neukoelln Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Henrich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Campus Rudolf\u2010Virchow, Charit\u00e9 Humboldt\u2010University Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Schlembach","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics Clinicum Vivantes Neukoelln Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Abou\u2010Dakn","sequence":"additional","affiliation":[{"name":"Berlin Center for Diabetes and Pregnancy Department of Obstetrics and Gynaecology St. Joseph Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3545-8009","authenticated-orcid":false,"given":"U. M.","family":"Schaefer\u2010Graf","sequence":"additional","affiliation":[{"name":"Berlin Center for Diabetes and Pregnancy Department of Obstetrics and Gynaecology St. Joseph Hospital Berlin Germany"},{"name":"Department of Obstetrics Campus Rudolf\u2010Virchow, Charit\u00e9 Humboldt\u2010University Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4314-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.03.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1647"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-2061"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3108-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0914"},{"key":"e_1_2_10_8_1","volume-title":"Diabetes in Pregnancy: Management of Diabetes and Its Complications from Preconception to the Postnatal Period","author":"National Collaborating Centre for Women\u2019s and Children\u2019s Health (UK)"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-S014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1113"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13398"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1066"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.554"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.806896"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1755"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-0958-0"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci17-0045"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2013.10.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/310239"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1036519"},{"key":"e_1_2_10_21_1","unstructured":"Weight Gain During Pregnancy: Reexamining the Guidelines 2009 Institute of Medicine (US) and National Research Council (US) Committee to Reexamine IOM Pregnancy Weight Guidelines"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-1974"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0244"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2721-z"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0070"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0958-7"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1134-z"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2684"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13861"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.3635"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32400-5"}],"container-title":["Diabetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdme.14350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.14350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dme.14350","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.14350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:21:09Z","timestamp":1693808469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.14350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,2]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/dme.14350"],"URL":"https:\/\/doi.org\/10.1111\/dme.14350","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738210664.793579171","asserted-by":"object"}]},"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,2]]},"assertion":[{"value":"2020-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}