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Eligible reports employed any type of genetically informed design, including twin modelling, Mendelian randomization, genome\u2010wide association studies, polygenetic risk scores, or linkage disequilibrium score regression. Searches generated 451 unique citations, and 16 manuscripts met the inclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The included studies addressed three aetiological models of the depression\u2013diabetes relationship: uni\u2010 or bi\u2010directional phenotypic causation; shared genetic liability; or gene\u2013environment interaction. From these studies, there is modest evidence that type 2 diabetes is causally related to risk of developing depression, but much more limited evidence that depression is causally related to risk of diabetes. There is little evidence of shared genetic liability between depression and diabetes or of gene\u2013environment interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings from genetically informed studies are mixed but provide some support for the uni\u2010 or bi\u2010directional phenotypic model of depression and type 2 diabetes. Future studies should also explore the hypothesis that this relationship may be influenced by shared environmental risk factors. Findings can inform multifaceted approaches to diabetes prevention and care that reflect how psychosocial factors contribute to type 2 diabetes risk and outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14399","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T01:15:19Z","timestamp":1600823719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Understanding the relationship between type 2 diabetes and depression: lessons from genetically informative study designs"],"prefix":"10.1111","volume":"38","author":[{"given":"R. S.","family":"Bergmans","sequence":"first","affiliation":[{"name":"Department of Psychiatry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rapp","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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