{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:12:31Z","timestamp":1758823951138,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E 26\/110.170\/2013"],"award-info":[{"award-number":["E 26\/110.170\/2013"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["563753\/2010\u20102"],"award-info":[{"award-number":["563753\/2010\u20102"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the relationship between self\u2010reported colour\u2010race, genomic ancestry, and metabolic syndrome in an admixed Brazilian population with type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 1640 participants with type 1 diabetes. The proportions of European, African and Amerindian genomic ancestries were determined by 46 ancestry informative markers of insertion deletion. Two different sets of analyses were performed to determine whether self\u2010reported colour\u2010race and genomic ancestry were predictors of metabolic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Metabolic syndrome was identified in 29.8% of participants. In the first model, the factors associated with metabolic syndrome were: female gender (odds ratio 1.95, <jats:italic>P<\/jats:italic> &lt; 0.001); diabetes duration (odds ratio 1.04, <jats:italic>P<\/jats:italic> &lt; 0.001); family history of type 2 diabetes (odds ratio 1.36, <jats:italic>P =<\/jats:italic> 0.019); and acanthosis nigricans (odds ratio 5.93, <jats:italic>P<\/jats:italic> &lt; 0.001). Colour\u2010race was not a predictive factor for metabolic syndrome. In the second model, colour\u2010race was replaced by European genomic ancestry. The associated factors were: female gender (odds ratio 1.95, <jats:italic>P<\/jats:italic> &lt; 0.001); diabetes duration (odds ratio 1.04, <jats:italic>P<\/jats:italic> &lt; 0.001); family history of type 2 diabetes (odds ratio 1.39, <jats:italic>P<\/jats:italic> = 0.011); and acanthosis nigricans (odds ratio 6.12, <jats:italic>P<\/jats:italic> &lt; 0.001). Physical exercise (\u22653 times a week) was a protective factor (odds ratio 0.77, <jats:italic>P<\/jats:italic> = 0.041), and European genomic ancestry was not associated with metabolic syndrome but showed an odds ratio of 1.77 (<jats:italic>P<\/jats:italic> = 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although a higher level of European genomic ancestry\u00a0was observed among participants with metabolic syndrome in the univariate analysis, this association did not persist after multivariable adjustments. Further prospective studies in other highly admixed populations remain necessary\u00a0to better evaluate whether the European ancestral component modulates the development of metabolic syndrome in type 1 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dme.14400","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T13:04:58Z","timestamp":1601039098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genomic ancestry and metabolic syndrome in individuals with type 1 diabetes from an admixed population: a multicentre, cross\u2010sectional study in Brazil"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-2378","authenticated-orcid":false,"given":"B. S. V.","family":"Barros","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Diabetes Unit State University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0412-3193","authenticated-orcid":false,"given":"D. C.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Diabetes Unit State University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-2213","authenticated-orcid":false,"given":"L. G. N.","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology State University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3787-7116","authenticated-orcid":false,"given":"M. H.","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Diabetes Unit State University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Muniz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Diabetes Unit State University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3805-2837","authenticated-orcid":false,"given":"D. A.","family":"Silva","sequence":"additional","affiliation":[{"name":"DNA Diagnostic Laboratory State University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-1821","authenticated-orcid":false,"given":"L. 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